Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models

Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models

Abstract Allergic rhinitis (AR) is caused by type I hypersensitivity reaction in the nasal tissues. The interaction between CD300f and its ligand ceramide suppresses immunoglobulin E (IgE)-mediated mast cell activation. However, whether CD300f inhibits the development of allergic rhinitis (AR) remai...

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Main Authors: Takuma Ide, Kumi Izawa, Wahyu Diono, Anna Kamei, Tomoaki Ando, Ayako Kaitani, Akie Maehara, Akihisa Yoshikawa, Risa Yamamoto, Shino Uchida, Hexing Wang, Mayuki Kojima, Keiko Maeda, Nobuhiro Nakano, Masahiro Nakamura, Toshiaki Shimizu, Hideoki Ogawa, Ko Okumura, Fumihiko Matsumoto, Katsuhisa Ikeda, Motonobu Goto, Jiro Kitaura
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-58923-w

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