Identification of novel CDK9 and Cyclin T1-associated protein complexes (CCAPs) whose siRNA depletion enhances HIV-1 Tat function
<p>Abstract</p> <p>Background</p> <p>HIV-1 Tat activates RNA Polymerase II (RNAP II) elongation of the integrated provirus by recruiting a protein kinase known as P-TEFb to TAR RNA at the 5<sup>′</sup> end of nascent viral transcripts. The catalytic core of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-10-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/9/1/90 |