Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training
Data on the effect of vitamin D (Vit-D) supplementation on cardiorespiratory fitness (VO<sub>2</sub>max) are conflicting. A possible source of discrepancies in the literature is the heterogeneity in baseline Vit-D status among participants in previous studies. The main objectives of the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/24/5302 |
| _version_ | 1797455873250951168 |
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| author | Lauri Savolainen Saima Timpmann Martin Mooses Luule Medijainen Lisette Tõnutare Frederik Ross Märt Lellsaar Anneli Piir Mihkel Zilmer Eve Unt Vahur Ööpik |
| author_facet | Lauri Savolainen Saima Timpmann Martin Mooses Luule Medijainen Lisette Tõnutare Frederik Ross Märt Lellsaar Anneli Piir Mihkel Zilmer Eve Unt Vahur Ööpik |
| author_sort | Lauri Savolainen |
| collection | DOAJ |
| description | Data on the effect of vitamin D (Vit-D) supplementation on cardiorespiratory fitness (VO<sub>2</sub>max) are conflicting. A possible source of discrepancies in the literature is the heterogeneity in baseline Vit-D status among participants in previous studies. The main objectives of the present study were to assess the impact of Vit-D supplementation on VO<sub>2</sub>max and inflammatory status in Vit-D deficient young healthy men. Participants (n = 39, baseline serum Vit-D level < 50 nmol/L) were quasi-randomly assigned to one of the two groups, which, in a double-blind manner, supplemented their diet daily with either Vit-D (8000 IU; VD) or placebo (PLC) and concomitantly performed a 12-week supervised resistance training program. During the 12-week intervention, serum Vit-D concentrations increased 3.9-fold (<i>p</i> < 0.001) in the VD group while no changes occurred in the PLC group. Baseline VO<sub>2</sub>max did not differ in the two groups and remained unchanged during the intervention. Serum interleukin-10/tumour necrosis factor alpha ratio increased significantly (30%, <i>p</i> = 0.007; effect size 0.399) in VD but not in PLC group. In conclusion, 12-week Vit-D supplementation increases serum 25(OH)D levels and improves inflammatory status, but has no impact on VO<sub>2</sub>max in Vit-D deficient young men engaged in resistance training. |
| first_indexed | 2024-03-09T16:00:27Z |
| format | Article |
| id | doaj.art-86f58fdafb084e958ad72419331d09a6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-86f58fdafb084e958ad72419331d09a62023-11-24T17:08:58ZengMDPI AGNutrients2072-66432022-12-011424530210.3390/nu14245302Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance TrainingLauri Savolainen0Saima Timpmann1Martin Mooses2Luule Medijainen3Lisette Tõnutare4Frederik Ross5Märt Lellsaar6Anneli Piir7Mihkel Zilmer8Eve Unt9Vahur Ööpik10Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, EstoniaDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, EstoniaDepartment of Cardiology, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, EstoniaInstitute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, EstoniaData on the effect of vitamin D (Vit-D) supplementation on cardiorespiratory fitness (VO<sub>2</sub>max) are conflicting. A possible source of discrepancies in the literature is the heterogeneity in baseline Vit-D status among participants in previous studies. The main objectives of the present study were to assess the impact of Vit-D supplementation on VO<sub>2</sub>max and inflammatory status in Vit-D deficient young healthy men. Participants (n = 39, baseline serum Vit-D level < 50 nmol/L) were quasi-randomly assigned to one of the two groups, which, in a double-blind manner, supplemented their diet daily with either Vit-D (8000 IU; VD) or placebo (PLC) and concomitantly performed a 12-week supervised resistance training program. During the 12-week intervention, serum Vit-D concentrations increased 3.9-fold (<i>p</i> < 0.001) in the VD group while no changes occurred in the PLC group. Baseline VO<sub>2</sub>max did not differ in the two groups and remained unchanged during the intervention. Serum interleukin-10/tumour necrosis factor alpha ratio increased significantly (30%, <i>p</i> = 0.007; effect size 0.399) in VD but not in PLC group. In conclusion, 12-week Vit-D supplementation increases serum 25(OH)D levels and improves inflammatory status, but has no impact on VO<sub>2</sub>max in Vit-D deficient young men engaged in resistance training.https://www.mdpi.com/2072-6643/14/24/5302vitamin Dcytokineslow-grade inflammationmaximal oxygen consumption |
| spellingShingle | Lauri Savolainen Saima Timpmann Martin Mooses Luule Medijainen Lisette Tõnutare Frederik Ross Märt Lellsaar Anneli Piir Mihkel Zilmer Eve Unt Vahur Ööpik Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training Nutrients vitamin D cytokines low-grade inflammation maximal oxygen consumption |
| title | Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training |
| title_full | Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training |
| title_fullStr | Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training |
| title_full_unstemmed | Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training |
| title_short | Vitamin D Supplementation Has No Impact on Cardiorespiratory Fitness, but Improves Inflammatory Status in Vitamin D Deficient Young Men Engaged in Resistance Training |
| title_sort | vitamin d supplementation has no impact on cardiorespiratory fitness but improves inflammatory status in vitamin d deficient young men engaged in resistance training |
| topic | vitamin D cytokines low-grade inflammation maximal oxygen consumption |
| url | https://www.mdpi.com/2072-6643/14/24/5302 |
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