Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses
Introduction Better evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD). One hallmark neurocognitive feature of ADHD is impaired inhibition, related to impulsivity. Given the high heritab...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822005909/type/journal_article |
| _version_ | 1797616860669149184 |
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| author | L. Balogh A. Pulay N. Angyal K. Vincze T. Kilencz Z. Nemoda J. Réthelyi |
| author_facet | L. Balogh A. Pulay N. Angyal K. Vincze T. Kilencz Z. Nemoda J. Réthelyi |
| author_sort | L. Balogh |
| collection | DOAJ |
| description |
Introduction
Better evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD). One hallmark neurocognitive feature of ADHD is impaired inhibition, related to impulsivity. Given the high heritability of ADHD, the assessment of genetic background of impaired inhibition may contribute to our knowledge about the genetic background of the disorder.
Objectives
In our study we investigated whether different forms of impulsivity (attentive, motor, and nonplanning) and polymorphisms in genes of the noradrenergic, serotonergic, and dopaminergic neurotransmission, i.e. dopamine transporter-1 (DAT1), cathecoloamin-O-metiltransferase (COMT), and serotonin receptor-1B (HTR1B genes show association.
Methods
208 aADHD patients diagnosed according to DSM-5 criteria from a clinical sample and 142 individuals from a population sample who screened positive for aADHD were included in the study. DNA samples were genotyped for the HTR-1B gene rs1321041 and the COMT gene rs4680 SNPs, moreover the DAT-1 VNTR polymorphism. Dimensional variables for impulsivity were compared between genotypes with the Generalized Linear Model procedure corrected for sex and age, using the PLINK 1.9 statistical software.
Results
The 9 repeat polymorphism in DAT1 was associated with the severity of hyperactivity, moreover, all impulsivity factors. The A allele in COMT was associated with hyperactivity and better motor inhibition activity. In carriers of the G allele in HTR1B we detected significantly higher inattention scores and increased reaction time.
Conclusions
Our results support the putative role of the investigated genetic polymorphisms in the etiology of impulsivity. Nevertheless, these polymorphisms demonstrate a heterogeneous associations.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:46:26Z |
| format | Article |
| id | doaj.art-86f65d84d6824878a469c6842267181c |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:46:26Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-86f65d84d6824878a469c6842267181c2023-11-17T05:07:30ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S227S22810.1192/j.eurpsy.2022.590Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analysesL. Balogh0A. Pulay1N. Angyal2K. Vincze3T. Kilencz4Z. Nemoda5J. Réthelyi6Semmelweis University, Department Of Psychiatry And Psychotherapy, Budapest, HungarySemmelweis University, Department Of Psychiatry And Psychotherapy, Budapest, HungarySemmelweis University, Department Of Biochemistry And Molecular Biology, Budapest, HungarySemmelweis University, Department Of Psychiatry And Psychotherapy, Budapest, HungarySemmelweis University, Department Of Psychiatry And Psychotherapy, Budapest, HungarySemmelweis University, Department Of Biochemistry And Molecular Biology, Budapest, HungarySemmelweis University, Department Of Psychiatry And Psychotherapy, Budapest, Hungary Introduction Better evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD). One hallmark neurocognitive feature of ADHD is impaired inhibition, related to impulsivity. Given the high heritability of ADHD, the assessment of genetic background of impaired inhibition may contribute to our knowledge about the genetic background of the disorder. Objectives In our study we investigated whether different forms of impulsivity (attentive, motor, and nonplanning) and polymorphisms in genes of the noradrenergic, serotonergic, and dopaminergic neurotransmission, i.e. dopamine transporter-1 (DAT1), cathecoloamin-O-metiltransferase (COMT), and serotonin receptor-1B (HTR1B genes show association. Methods 208 aADHD patients diagnosed according to DSM-5 criteria from a clinical sample and 142 individuals from a population sample who screened positive for aADHD were included in the study. DNA samples were genotyped for the HTR-1B gene rs1321041 and the COMT gene rs4680 SNPs, moreover the DAT-1 VNTR polymorphism. Dimensional variables for impulsivity were compared between genotypes with the Generalized Linear Model procedure corrected for sex and age, using the PLINK 1.9 statistical software. Results The 9 repeat polymorphism in DAT1 was associated with the severity of hyperactivity, moreover, all impulsivity factors. The A allele in COMT was associated with hyperactivity and better motor inhibition activity. In carriers of the G allele in HTR1B we detected significantly higher inattention scores and increased reaction time. Conclusions Our results support the putative role of the investigated genetic polymorphisms in the etiology of impulsivity. Nevertheless, these polymorphisms demonstrate a heterogeneous associations. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822005909/type/journal_articleadhdImpulsivityDAT1hyperactivity |
| spellingShingle | L. Balogh A. Pulay N. Angyal K. Vincze T. Kilencz Z. Nemoda J. Réthelyi Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses European Psychiatry adhd Impulsivity DAT1 hyperactivity |
| title | Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses |
| title_full | Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses |
| title_fullStr | Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses |
| title_full_unstemmed | Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses |
| title_short | Upside down: dissecting impulsivity in attention-deficit hyperactivity disorder through genotype-phenotype association analyses |
| title_sort | upside down dissecting impulsivity in attention deficit hyperactivity disorder through genotype phenotype association analyses |
| topic | adhd Impulsivity DAT1 hyperactivity |
| url | https://www.cambridge.org/core/product/identifier/S0924933822005909/type/journal_article |
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