Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature
Background: A diagnosis of "idiopathic short stature" (ISS) in a child means that the cause of the disease has not been established, although there are certainly some unknown factors that contributed to its occurrence. Ghrelin and leptin are important in controlling food intake; ghrelin is...
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/19/5868 |
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| author | Marzena Kolasa-Kicińska Renata Stawerska Paweł Stawerski Andrzej Kałużyński Elżbieta Czkwianianc Andrzej Lewiński |
| author_facet | Marzena Kolasa-Kicińska Renata Stawerska Paweł Stawerski Andrzej Kałużyński Elżbieta Czkwianianc Andrzej Lewiński |
| author_sort | Marzena Kolasa-Kicińska |
| collection | DOAJ |
| description | Background: A diagnosis of "idiopathic short stature" (ISS) in a child means that the cause of the disease has not been established, although there are certainly some unknown factors that contributed to its occurrence. Ghrelin and leptin are important in controlling food intake; ghrelin is also a growth hormone (GH) stimulator. Both enterohormones are produced in the stomach and their secretion may be affected by a <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection. Methods: Our study included a group of 61 children (53 prepubertal and 8 peripubertal) with ISS, without any gastrointestinal tract symptoms but in whom the histopathological evaluation of stomach tissue was made during gastroscopy to diagnose <i>H. pylori</i> infection. In each child, fasting ghrelin, leptin and IGF-1 concentrations, and GH levels in two stimulation tests were assessed. Results: <i>H. pylori</i> infection was confirmed in 24.6% of the children. Ghrelin and IGF-1 concentrations were significantly lower in <i>H. pylori</i>-positive than <i>H. pylori</i>-negative children (this was more noticeable in prepubertal subgroups), however there was not a discrepancy in regards to GH concentrations in stimulation tests, leptin levels or the nutritional state between groups. Conclusions: Short children, infected by <i>H. pylori</i> seem to have lower ghrelin and IGF-1 concentrations than children without infection, this may be the reason for a worse growth rate in this subgroup. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:33:28Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-86f7ab9d736940cfa83d5e4d83bfc4832023-11-23T20:50:11ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011119586810.3390/jcm11195868Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short StatureMarzena Kolasa-Kicińska0Renata Stawerska1Paweł Stawerski2Andrzej Kałużyński3Elżbieta Czkwianianc4Andrzej Lewiński5Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, PolandDepartment of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, PolandConsilio Diagnostyka, Laboratory of Histopathology, 93-357 Lodz, PolandDepartment of Clinical Pathomorphology, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, PolandDepartment of Gastroenterology, Allergology and Paediatrics, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, PolandDepartment of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital–Research Institute, 93-338 Lodz, PolandBackground: A diagnosis of "idiopathic short stature" (ISS) in a child means that the cause of the disease has not been established, although there are certainly some unknown factors that contributed to its occurrence. Ghrelin and leptin are important in controlling food intake; ghrelin is also a growth hormone (GH) stimulator. Both enterohormones are produced in the stomach and their secretion may be affected by a <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection. Methods: Our study included a group of 61 children (53 prepubertal and 8 peripubertal) with ISS, without any gastrointestinal tract symptoms but in whom the histopathological evaluation of stomach tissue was made during gastroscopy to diagnose <i>H. pylori</i> infection. In each child, fasting ghrelin, leptin and IGF-1 concentrations, and GH levels in two stimulation tests were assessed. Results: <i>H. pylori</i> infection was confirmed in 24.6% of the children. Ghrelin and IGF-1 concentrations were significantly lower in <i>H. pylori</i>-positive than <i>H. pylori</i>-negative children (this was more noticeable in prepubertal subgroups), however there was not a discrepancy in regards to GH concentrations in stimulation tests, leptin levels or the nutritional state between groups. Conclusions: Short children, infected by <i>H. pylori</i> seem to have lower ghrelin and IGF-1 concentrations than children without infection, this may be the reason for a worse growth rate in this subgroup.https://www.mdpi.com/2077-0383/11/19/5868idiopathic short statureghrelinleptinIGF-1<i>Helicobacter pylori</i>children |
| spellingShingle | Marzena Kolasa-Kicińska Renata Stawerska Paweł Stawerski Andrzej Kałużyński Elżbieta Czkwianianc Andrzej Lewiński Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature Journal of Clinical Medicine idiopathic short stature ghrelin leptin IGF-1 <i>Helicobacter pylori</i> children |
| title | Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature |
| title_full | Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature |
| title_fullStr | Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature |
| title_full_unstemmed | Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature |
| title_short | Effects of <i>Helicobacter pylori</i> Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature |
| title_sort | effects of i helicobacter pylori i infection on ghrelin and insulin like growth factor 1 secretion in children with idiopathic short stature |
| topic | idiopathic short stature ghrelin leptin IGF-1 <i>Helicobacter pylori</i> children |
| url | https://www.mdpi.com/2077-0383/11/19/5868 |
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