Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

Acute sterol o-acyltransferase 2 (SOAT2) knockdown rapidly mobilizes hepatic cholesterol for fecal excretion.

The primary risk factor for atherosclerotic cardiovascular disease is LDL cholesterol, which can be reduced by increasing cholesterol excretion from the body. Fecal cholesterol excretion can be driven by a hepatobiliary as well as a non-biliary pathway known as transintestinal cholesterol efflux (TI...

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Bibliographic Details
Main Authors: Stephanie M Marshall, Anthony D Gromovsky, Kathryn L Kelley, Matthew A Davis, Martha D Wilson, Richard G Lee, Rosanne M Crooke, Mark J Graham, Lawrence L Rudel, J Mark Brown, Ryan E Temel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4047063?pdf=render

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