A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count

A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count

Abstract Background Chimeric antigen receptor T (CAR-T) cells are genetically modified T cells with redirected specificity and potent T-cell-mediated cytotoxicity toward malignant cells. Despite several CAR-T products being approved and commercialized in the USA, Europe, and China, CAR-T products st...

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Bibliographic Details
Main Authors: Haiying Wang, Shih-Ting Tsao, Mingyuan Gu, Chengbing Fu, Feng He, Xiu Li, Mian Zhang, Na Li, Hong-Ming Hu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Chimeric antigen receptor T (CAR-T) cells
T-cell purification
T-cell activation
Monocyte
Design of experiments (DoE)
Online Access:https://doi.org/10.1186/s12967-022-03833-6

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