Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
Epigenetic regulations, that comprise histone modifications and DNA methylation, are essential to processes as diverse as development and cancer. Among the histone post-translational modifications, lysine methylation represents one of the most important dynamic marks. Here, we focused on methyltrans...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/19/4865 |
| _version_ | 1797480157821272064 |
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| author | Imène Krossa Thomas Strub Andrew E. Aplin Robert Ballotti Corine Bertolotto |
| author_facet | Imène Krossa Thomas Strub Andrew E. Aplin Robert Ballotti Corine Bertolotto |
| author_sort | Imène Krossa |
| collection | DOAJ |
| description | Epigenetic regulations, that comprise histone modifications and DNA methylation, are essential to processes as diverse as development and cancer. Among the histone post-translational modifications, lysine methylation represents one of the most important dynamic marks. Here, we focused on methyltransferases of the nuclear binding SET domain 1 (NSD) family, that catalyze the mono- and di-methylation of histone H3 lysine 36. We review the loss of function mutations of <i>NSD1</i> in humans that are the main cause of SOTOS syndrome, a disease associated with an increased risk of developing cancer. We then report the role of NSD1 in triggering tumor suppressive or promoter functions according to the tissue context and we discuss the role of NSD1 in melanoma. Finally, we examine the ongoing efforts to target NSD1 signaling in cancers. |
| first_indexed | 2024-03-09T21:55:52Z |
| format | Article |
| id | doaj.art-86fc85a951e14150aa2889911470ecb8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T21:55:52Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-86fc85a951e14150aa2889911470ecb82023-11-23T19:57:52ZengMDPI AGCancers2072-66942022-10-011419486510.3390/cancers14194865Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?Imène Krossa0Thomas Strub1Andrew E. Aplin2Robert Ballotti3Corine Bertolotto4Université Côte d’Azur, 06100 Nice, FranceUniversité Côte d’Azur, 06100 Nice, FranceDepartment of Pharmacology, Physiology, and Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USAUniversité Côte d’Azur, 06100 Nice, FranceUniversité Côte d’Azur, 06100 Nice, FranceEpigenetic regulations, that comprise histone modifications and DNA methylation, are essential to processes as diverse as development and cancer. Among the histone post-translational modifications, lysine methylation represents one of the most important dynamic marks. Here, we focused on methyltransferases of the nuclear binding SET domain 1 (NSD) family, that catalyze the mono- and di-methylation of histone H3 lysine 36. We review the loss of function mutations of <i>NSD1</i> in humans that are the main cause of SOTOS syndrome, a disease associated with an increased risk of developing cancer. We then report the role of NSD1 in triggering tumor suppressive or promoter functions according to the tissue context and we discuss the role of NSD1 in melanoma. Finally, we examine the ongoing efforts to target NSD1 signaling in cancers.https://www.mdpi.com/2072-6694/14/19/4865epigeneticscancersmelanomatherapies |
| spellingShingle | Imène Krossa Thomas Strub Andrew E. Aplin Robert Ballotti Corine Bertolotto Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? Cancers epigenetics cancers melanoma therapies |
| title | Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? |
| title_full | Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? |
| title_fullStr | Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? |
| title_full_unstemmed | Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? |
| title_short | Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma? |
| title_sort | lysine methyltransferase nsd1 and cancers any role in melanoma |
| topic | epigenetics cancers melanoma therapies |
| url | https://www.mdpi.com/2072-6694/14/19/4865 |
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