Recombinant L. lactis vaccine LL-plSAM-WAE targeting four virulence factors provides mucosal immunity against H. pylori infection

Recombinant L. lactis vaccine LL-plSAM-WAE targeting four virulence factors provides mucosal immunity against H. pylori infection

Abstract Background Helicobacter pylori (H. pylori) causes chronic gastric disease. An efficient oral vaccine would be mucosa-targeted and offer defense against colonization of invasive infection in the digestive system. Proteolytic enzymes and acidic environment in the gastrointestinal tract (GT) c...

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Bibliographic Details
Main Authors: Furui Zhang, Linhan Ni, Zhen Zhang, Xuegang Luo, Xuequan Wang, Wenmiao Zhou, Jiale Chen, Jing Liu, Yuliang Qu, Kunmei Liu, Le Guo
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Microbial Cell Factories
Subjects:
Helicobacter pylori
Lactic acid bacteria
M cell-targeting
Vaccine delivery system
Mucosal immune response
Online Access:https://doi.org/10.1186/s12934-024-02321-4

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