Non-Alcoholic Fatty Liver Disease (NAFLD) in Obesity
Background and Objectives: Limited studies have been undertaken to characterize Non-Alcoholic Fatty Liver Disease (NAFLD) in the Indian population. The main objective of our study was to document the prevalence of NAFLD amongst a cohort of obese Indian patients and demonstrate its relationship...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3953/18-6691_CE(Ra)_F(H)_PF1(RAK)_PFA(H)_NEW_PF2(NJSH).pdf |
| Summary: | Background and Objectives: Limited studies have been
undertaken to characterize Non-Alcoholic Fatty Liver Disease
(NAFLD) in the Indian population. The main objective of our
study was to document the prevalence of NAFLD amongst a
cohort of obese Indian patients and demonstrate its relationship
with other components of the metabolic syndrome.
Methods: A total of 60 adult obese patients were subjected
to a detailed history, clinical exam, anthropometric study and
laboratory workup. Focus was on liver function and components
of the metabolic syndrome like blood pressure, glycemic status
and lipid profile. Subjects enrolled were divided into two groups
Group A (n=48), with NAFLD and Group B (n=12) without NAFLD.
The two groups were then compared amongst themselves as
well as with data from previous similar studies.
Results: A comparison of the anthropometric measurements
revealed a statistically significant difference between the Body
mass index (BMI) and Waist Hip Ratio of the two groups and in the
mean triglyceride values between the two groups. Although the
mean bilirubin levels measured in the serum were not statistically
different the mean levels of SGOT and SGPT in the two groups
was found to be statistically significant. On the contrary no
significant difference in the values of alkaline phosphatase and
synthetic liver functions could be discerned. A statistically highly
significant difference in the mean liver span is seen.
Interpretation and Conclusions: NAFLD is common in Indian
obese populations and is associated with significant differences
in anthropometric, clinical, laboratory and ultrasonographic
aspects as compared with obese individuals not affected with
liver disease. |
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| ISSN: | 2249-782X 0973-709X |