Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Ru Ma,1– 3 Hongling Su,1– 3 Keping Jiao,1– 3 Jian Liu1,2 1The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China; 2Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China; 3Gansu Provincial People’s Hospital, Lanzhou, G...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | International Journal of COPD |
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| Online Access: | https://www.dovepress.com/association-between-il-17-and-chronic-obstructive-pulmonary-disease-a--peer-reviewed-fulltext-article-COPD |
| _version_ | 1827877951747653632 |
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| author | Ma R Su H Jiao K Liu J |
| author_facet | Ma R Su H Jiao K Liu J |
| author_sort | Ma R |
| collection | DOAJ |
| description | Ru Ma,1– 3 Hongling Su,1– 3 Keping Jiao,1– 3 Jian Liu1,2 1The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China; 2Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China; 3Gansu Provincial People’s Hospital, Lanzhou, Gansu Province, People’s Republic of ChinaCorrespondence: Jian Liu, Department of Clinical Medicine, the First Clinical Medical College of Lanzhou University, No. 1, Donggang West Road, Chengguan District, Lanzhou City, Gansu Province, People’s Republic of China, Tel +86 136 0935 4197, Email medecinliu@sina.comBackground: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by neutrophils airway infiltration. It is currently known that Interleukin-17 (IL-17) is an important pro-inflammatory factor. It can promote the accumulation of neutrophils and participate in the chronic inflammatory process of COPD. However, the value of IL-17 levels in the diagnosis and assessment of COPD remains controversial. In view of this, we conducted a systematic review and meta-analysis to assess its relevance.Methods: We searched databases such as PubMed, Web of Science, Cochrane Library and Embase to extract original research.Results: A total of 10 studies with 2268 participants were included in this meta-analysis. The results showed that the level of serum IL-17 in patients with stable COPD was significantly higher than that in healthy controls (standard mean difference SMD, 1.59, 95% CI 0.84– 2.34; p< 0.001). Compared with the stable COPD group, the serum IL-17 level in acute exacerbation (AECOPD) was significantly higher (SMD, 1.78, 95% CI 1.22– 2.33; p< 0.001). The level of IL-17 in sputum of COPD patients was also higher than that of healthy controls (SMD, 2.03, 95% CI 0.74– 3.31; p< 0.001).Conclusion: Our results showed that IL-17 levels were elevated in serum and sputum in COPD patients compared with healthy controls, and IL-17 levels increased with disease progression. IL-17 serves as a potential biomarker to indicate the persistence of neutrophilic inflammation and exacerbation of COPD.Keywords: chronic obstructive pulmonary disease, Interleukin-17, proinflammatory factor, meta-analysis |
| first_indexed | 2024-03-12T17:44:44Z |
| format | Article |
| id | doaj.art-87043b4ba6594cb2a8700b961d9ca39a |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-03-12T17:44:44Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-87043b4ba6594cb2a8700b961d9ca39a2023-08-03T19:02:11ZengDove Medical PressInternational Journal of COPD1178-20052023-08-01Volume 181681169085611Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-AnalysisMa RSu HJiao KLiu JRu Ma,1– 3 Hongling Su,1– 3 Keping Jiao,1– 3 Jian Liu1,2 1The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China; 2Lanzhou University, Lanzhou City, Gansu Province, People’s Republic of China; 3Gansu Provincial People’s Hospital, Lanzhou, Gansu Province, People’s Republic of ChinaCorrespondence: Jian Liu, Department of Clinical Medicine, the First Clinical Medical College of Lanzhou University, No. 1, Donggang West Road, Chengguan District, Lanzhou City, Gansu Province, People’s Republic of China, Tel +86 136 0935 4197, Email medecinliu@sina.comBackground: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by neutrophils airway infiltration. It is currently known that Interleukin-17 (IL-17) is an important pro-inflammatory factor. It can promote the accumulation of neutrophils and participate in the chronic inflammatory process of COPD. However, the value of IL-17 levels in the diagnosis and assessment of COPD remains controversial. In view of this, we conducted a systematic review and meta-analysis to assess its relevance.Methods: We searched databases such as PubMed, Web of Science, Cochrane Library and Embase to extract original research.Results: A total of 10 studies with 2268 participants were included in this meta-analysis. The results showed that the level of serum IL-17 in patients with stable COPD was significantly higher than that in healthy controls (standard mean difference SMD, 1.59, 95% CI 0.84– 2.34; p< 0.001). Compared with the stable COPD group, the serum IL-17 level in acute exacerbation (AECOPD) was significantly higher (SMD, 1.78, 95% CI 1.22– 2.33; p< 0.001). The level of IL-17 in sputum of COPD patients was also higher than that of healthy controls (SMD, 2.03, 95% CI 0.74– 3.31; p< 0.001).Conclusion: Our results showed that IL-17 levels were elevated in serum and sputum in COPD patients compared with healthy controls, and IL-17 levels increased with disease progression. IL-17 serves as a potential biomarker to indicate the persistence of neutrophilic inflammation and exacerbation of COPD.Keywords: chronic obstructive pulmonary disease, Interleukin-17, proinflammatory factor, meta-analysishttps://www.dovepress.com/association-between-il-17-and-chronic-obstructive-pulmonary-disease-a--peer-reviewed-fulltext-article-COPDchronic obstructive pulmonary disease;interleukin-17;proinflammtory factor;meta-analysis |
| spellingShingle | Ma R Su H Jiao K Liu J Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis International Journal of COPD chronic obstructive pulmonary disease;interleukin-17;proinflammtory factor;meta-analysis |
| title | Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_full | Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_fullStr | Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_short | Association Between IL-17 and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis |
| title_sort | association between il 17 and chronic obstructive pulmonary disease a systematic review and meta analysis |
| topic | chronic obstructive pulmonary disease;interleukin-17;proinflammtory factor;meta-analysis |
| url | https://www.dovepress.com/association-between-il-17-and-chronic-obstructive-pulmonary-disease-a--peer-reviewed-fulltext-article-COPD |
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