microRNA profiles and functions in mosquitoes.
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-05-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC5951587?pdf=render |
| _version_ | 1811338266742358016 |
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| author | Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu |
| author_facet | Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu |
| author_sort | Xinyu Feng |
| collection | DOAJ |
| description | Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms. Depending on the study, we found that miRNAs were dysregulated in a species-, sex-, stage-, and tissue/organ-specific manner. Aberrant miRNA expressions were observed in development, metabolism, host-pathogen interactions, and insecticide resistance. Of note, many miRNAs were down-regulated upon pathogen infection. The experimental studies have expanded the identification of miRNA target from the 3' untranslated regions (UTRs) of mRNAs of mosquitoes to the 5' UTRs of mRNAs of the virus. In addition, we discuss current trends in mosquito miRNA research and offer suggestions for future studies. |
| first_indexed | 2024-04-13T18:08:26Z |
| format | Article |
| id | doaj.art-8704c2dbe01a469d818de92d50af90aa |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-13T18:08:26Z |
| publishDate | 2018-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-8704c2dbe01a469d818de92d50af90aa2022-12-22T02:36:00ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352018-05-01125e000646310.1371/journal.pntd.0006463microRNA profiles and functions in mosquitoes.Xinyu FengShuisen ZhouJingwen WangWei HuMosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms. Depending on the study, we found that miRNAs were dysregulated in a species-, sex-, stage-, and tissue/organ-specific manner. Aberrant miRNA expressions were observed in development, metabolism, host-pathogen interactions, and insecticide resistance. Of note, many miRNAs were down-regulated upon pathogen infection. The experimental studies have expanded the identification of miRNA target from the 3' untranslated regions (UTRs) of mRNAs of mosquitoes to the 5' UTRs of mRNAs of the virus. In addition, we discuss current trends in mosquito miRNA research and offer suggestions for future studies.http://europepmc.org/articles/PMC5951587?pdf=render |
| spellingShingle | Xinyu Feng Shuisen Zhou Jingwen Wang Wei Hu microRNA profiles and functions in mosquitoes. PLoS Neglected Tropical Diseases |
| title | microRNA profiles and functions in mosquitoes. |
| title_full | microRNA profiles and functions in mosquitoes. |
| title_fullStr | microRNA profiles and functions in mosquitoes. |
| title_full_unstemmed | microRNA profiles and functions in mosquitoes. |
| title_short | microRNA profiles and functions in mosquitoes. |
| title_sort | microrna profiles and functions in mosquitoes |
| url | http://europepmc.org/articles/PMC5951587?pdf=render |
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