Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we perfo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-09-01
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| Series: | Genomics Data |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213596015000689 |
| _version_ | 1818765700435542016 |
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| author | S.T. Nurnberg K. Cheng A. Raiesdana R. Kundu C.L. Miller J.B. Kim K. Arora I. Carcamo-Oribe Y. Xiong N. Tellakula V. Nanda N. Murthy W.A. Boisvert U. Hedin L. Perisic S. Aldi L. Maegdefessel M. Pjanic G.K. Owens M.D. Tallquist T. Quertermous |
| author_facet | S.T. Nurnberg K. Cheng A. Raiesdana R. Kundu C.L. Miller J.B. Kim K. Arora I. Carcamo-Oribe Y. Xiong N. Tellakula V. Nanda N. Murthy W.A. Boisvert U. Hedin L. Perisic S. Aldi L. Maegdefessel M. Pjanic G.K. Owens M.D. Tallquist T. Quertermous |
| author_sort | S.T. Nurnberg |
| collection | DOAJ |
| description | TCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461). |
| first_indexed | 2024-12-18T08:22:16Z |
| format | Article |
| id | doaj.art-8706b8472de64931b56ff357508efdf9 |
| institution | Directory Open Access Journal |
| issn | 2213-5960 |
| language | English |
| last_indexed | 2024-12-18T08:22:16Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genomics Data |
| spelling | doaj.art-8706b8472de64931b56ff357508efdf92022-12-21T21:14:42ZengElsevierGenomics Data2213-59602015-09-015C363710.1016/j.gdata.2015.05.007Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous capS.T. Nurnberg0K. Cheng1A. Raiesdana2R. Kundu3C.L. Miller4J.B. Kim5K. Arora6I. Carcamo-Oribe7Y. Xiong8N. Tellakula9V. Nanda10N. Murthy11W.A. Boisvert12U. Hedin13L. Perisic14S. Aldi15L. Maegdefessel16M. Pjanic17G.K. Owens18M.D. Tallquist19T. Quertermous20Department of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesCenter for Cardiovascular Research, University of Hawaii, Honolulu, HI 96813, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesCenter for Cardiovascular Research, University of Hawaii, Honolulu, HI 96813, United StatesDepartments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, SwedenDepartments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, SwedenDepartments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, SwedenDepartments of Molecular Medicine and Surgery and Medicine, Karolinska Institute, 17176 Stockholm, SwedenDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, United StatesCenter for Cardiovascular Research, University of Hawaii, Honolulu, HI 96813, United StatesDepartment of Medicine, Cardiovascular Research Institute, Stanford University School of Medicine, Stanford, CA 94305, United StatesTCF21 is a basic helix–loop–helix transcription factor that has recently been implicated as contributing to susceptibility to coronary heart disease based on genome wide association studies. In order to identify transcriptionally regulated target genes in a major disease relevant cell type, we performed siRNA knockdown of TCF21 in in vitro cultured human coronary artery smooth muscle cells and compared the transcriptome of siTCF21 versus siCONTROL treated cells. The raw (FASTQ) as well as processed (BED) data from 3 technical replicates per treatment has been deposited with Gene Expression Omnibus (GSE44461).http://www.sciencedirect.com/science/article/pii/S2213596015000689 |
| spellingShingle | S.T. Nurnberg K. Cheng A. Raiesdana R. Kundu C.L. Miller J.B. Kim K. Arora I. Carcamo-Oribe Y. Xiong N. Tellakula V. Nanda N. Murthy W.A. Boisvert U. Hedin L. Perisic S. Aldi L. Maegdefessel M. Pjanic G.K. Owens M.D. Tallquist T. Quertermous Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap Genomics Data |
| title | Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap |
| title_full | Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap |
| title_fullStr | Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap |
| title_full_unstemmed | Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap |
| title_short | Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap |
| title_sort | coronary artery disease associated transcription factor tcf21 regulates smooth muscle precursor cells that contribute to the fibrous cap |
| url | http://www.sciencedirect.com/science/article/pii/S2213596015000689 |
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