Excipient-API interactions in dry powder inhalers
There remains a paucity of predictive models to evaluate the suitability of excipients or excipient mixtures for dry powder inhalers because a large number of interdependent variables affect both formulation and inhaler performance. The problem is compounded by empirical studies that are performed u...
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| Format: | Article |
| Language: | English |
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International Pharmaceutical Excipients Council
2016-11-01
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| Series: | Journal of Excipients and Food Chemicals |
| Online Access: | https://jefc.scholasticahq.com/article/1103-excipient-api-interactions-in-dry-powder-inhalers |
| _version_ | 1797254384605724672 |
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| author | Shireesh Apte |
| author_facet | Shireesh Apte |
| author_sort | Shireesh Apte |
| collection | DOAJ |
| description | There remains a paucity of predictive models to evaluate the suitability of excipients or excipient mixtures for dry powder inhalers because a large number of interdependent variables affect both formulation and inhaler
performance. The problem is compounded by empirical studies that are performed under different experimental conditions which make data comparison difficult. An easily calculable molecular parameter, the Parachor, relates structural constants to surface tension. When applied in conjunction with results obtained from inverse gas chromatography, the Parachor can be used to calculate adhesive and cohesive surface energies between excipients and active pharmaceutical ingredients. Values calculated from the Parachor are consistent with qualitative hypotheses and agree reasonably well with published quantitative results. The ability to both achieve and predict the free particle fraction from Parachor derived surface energy data represents a new paradigm worthy of further perusal. |
| first_indexed | 2024-04-24T21:49:06Z |
| format | Article |
| id | doaj.art-8707942e30dd4bd0af53aedff6073783 |
| institution | Directory Open Access Journal |
| issn | 2150-2668 |
| language | English |
| last_indexed | 2024-04-24T21:49:06Z |
| publishDate | 2016-11-01 |
| publisher | International Pharmaceutical Excipients Council |
| record_format | Article |
| series | Journal of Excipients and Food Chemicals |
| spelling | doaj.art-8707942e30dd4bd0af53aedff60737832024-03-20T18:01:37ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-26682016-11-0134Excipient-API interactions in dry powder inhalersShireesh ApteThere remains a paucity of predictive models to evaluate the suitability of excipients or excipient mixtures for dry powder inhalers because a large number of interdependent variables affect both formulation and inhaler performance. The problem is compounded by empirical studies that are performed under different experimental conditions which make data comparison difficult. An easily calculable molecular parameter, the Parachor, relates structural constants to surface tension. When applied in conjunction with results obtained from inverse gas chromatography, the Parachor can be used to calculate adhesive and cohesive surface energies between excipients and active pharmaceutical ingredients. Values calculated from the Parachor are consistent with qualitative hypotheses and agree reasonably well with published quantitative results. The ability to both achieve and predict the free particle fraction from Parachor derived surface energy data represents a new paradigm worthy of further perusal.https://jefc.scholasticahq.com/article/1103-excipient-api-interactions-in-dry-powder-inhalers |
| spellingShingle | Shireesh Apte Excipient-API interactions in dry powder inhalers Journal of Excipients and Food Chemicals |
| title | Excipient-API interactions in dry powder inhalers |
| title_full | Excipient-API interactions in dry powder inhalers |
| title_fullStr | Excipient-API interactions in dry powder inhalers |
| title_full_unstemmed | Excipient-API interactions in dry powder inhalers |
| title_short | Excipient-API interactions in dry powder inhalers |
| title_sort | excipient api interactions in dry powder inhalers |
| url | https://jefc.scholasticahq.com/article/1103-excipient-api-interactions-in-dry-powder-inhalers |
| work_keys_str_mv | AT shireeshapte excipientapiinteractionsindrypowderinhalers |