Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum
A worldwide increase in longevity is bringing novel challenges to public health and health care professionals. Cognitive impairment in the elderly may compromise living conditions and precede Alzheimer’s disease (AD), the most prevalent form of dementia. Therefore, finding molecular markers associat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.663837/full |
| _version_ | 1818441446985826304 |
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| author | Sofia Pereira das Neves Sofia Pereira das Neves Ricardo Taipa Ricardo Taipa Ricardo Taipa Fernanda Marques Fernanda Marques Patrício Soares Costa Patrício Soares Costa Joel Monárrez-Espino Joana A. Palha Joana A. Palha Miia Kivipelto Miia Kivipelto |
| author_facet | Sofia Pereira das Neves Sofia Pereira das Neves Ricardo Taipa Ricardo Taipa Ricardo Taipa Fernanda Marques Fernanda Marques Patrício Soares Costa Patrício Soares Costa Joel Monárrez-Espino Joana A. Palha Joana A. Palha Miia Kivipelto Miia Kivipelto |
| author_sort | Sofia Pereira das Neves |
| collection | DOAJ |
| description | A worldwide increase in longevity is bringing novel challenges to public health and health care professionals. Cognitive impairment in the elderly may compromise living conditions and precede Alzheimer’s disease (AD), the most prevalent form of dementia. Therefore, finding molecular markers associated with cognitive impairment is of crucial importance. Lipocalin 2 (LCN2), an iron-related protein, has been suggested as a potential marker for mild cognitive impairment (MCI) and AD. This study aimed at investigating the association between LCN2 measured in serum and cerebrospinal fluid (CSF) with cognitive impairment. A cross-sectional design based on two aging cohorts was used: individuals diagnosed with subjective cognitive complaints (SCC), MCI, and AD from a Swedish memory clinic-based cohort, and individuals diagnosed with SCC and AD from a Portuguese cohort. Binary logistic [for the outcome cognitive impairment (MCI + AD) in the Swedish cohort and AD in the Portuguese cohort] and multinomial logistic (for the outcomes MCI and AD) regression analyses were used. No associations were found in both cohorts when controlling for sex, education, and age. This explanatory study suggests that the association between serum and CSF LCN2 concentrations with cognitive impairment reported in the literature must be further analyzed for confounders. |
| first_indexed | 2024-12-14T18:28:23Z |
| format | Article |
| id | doaj.art-870bd4bcd52b4078894b12f194d1b7a7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-14T18:28:23Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-870bd4bcd52b4078894b12f194d1b7a72022-12-21T22:51:52ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-06-011310.3389/fnagi.2021.663837663837Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and SerumSofia Pereira das Neves0Sofia Pereira das Neves1Ricardo Taipa2Ricardo Taipa3Ricardo Taipa4Fernanda Marques5Fernanda Marques6Patrício Soares Costa7Patrício Soares Costa8Joel Monárrez-Espino9Joana A. Palha10Joana A. Palha11Miia Kivipelto12Miia Kivipelto13Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, PortugalDepartment of Neurosciences, Centro Hospitalar do Porto, Porto, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, PortugalDepartment of Health Research, Christus Muguerza Hospital—University of Monterrey, Chihuahua, MexicoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, PortugalDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenTheme Aging, Karolinska University Hospital, Stockholm, SwedenA worldwide increase in longevity is bringing novel challenges to public health and health care professionals. Cognitive impairment in the elderly may compromise living conditions and precede Alzheimer’s disease (AD), the most prevalent form of dementia. Therefore, finding molecular markers associated with cognitive impairment is of crucial importance. Lipocalin 2 (LCN2), an iron-related protein, has been suggested as a potential marker for mild cognitive impairment (MCI) and AD. This study aimed at investigating the association between LCN2 measured in serum and cerebrospinal fluid (CSF) with cognitive impairment. A cross-sectional design based on two aging cohorts was used: individuals diagnosed with subjective cognitive complaints (SCC), MCI, and AD from a Swedish memory clinic-based cohort, and individuals diagnosed with SCC and AD from a Portuguese cohort. Binary logistic [for the outcome cognitive impairment (MCI + AD) in the Swedish cohort and AD in the Portuguese cohort] and multinomial logistic (for the outcomes MCI and AD) regression analyses were used. No associations were found in both cohorts when controlling for sex, education, and age. This explanatory study suggests that the association between serum and CSF LCN2 concentrations with cognitive impairment reported in the literature must be further analyzed for confounders.https://www.frontiersin.org/articles/10.3389/fnagi.2021.663837/fullAlzheimer’s diseasemild-cognitive impairmentcognitionlipocalin 2biomarker |
| spellingShingle | Sofia Pereira das Neves Sofia Pereira das Neves Ricardo Taipa Ricardo Taipa Ricardo Taipa Fernanda Marques Fernanda Marques Patrício Soares Costa Patrício Soares Costa Joel Monárrez-Espino Joana A. Palha Joana A. Palha Miia Kivipelto Miia Kivipelto Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum Frontiers in Aging Neuroscience Alzheimer’s disease mild-cognitive impairment cognition lipocalin 2 biomarker |
| title | Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum |
| title_full | Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum |
| title_fullStr | Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum |
| title_full_unstemmed | Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum |
| title_short | Association Between Iron-Related Protein Lipocalin 2 and Cognitive Impairment in Cerebrospinal Fluid and Serum |
| title_sort | association between iron related protein lipocalin 2 and cognitive impairment in cerebrospinal fluid and serum |
| topic | Alzheimer’s disease mild-cognitive impairment cognition lipocalin 2 biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.663837/full |
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