Mice lacking γENaC palmitoylation sites maintain benzamil-sensitive Na+ transport despite reduced channel activity

Mice lacking γENaC palmitoylation sites maintain benzamil-sensitive Na+ transport despite reduced channel activity

Epithelial Na+ channels (ENaCs) control extracellular fluid volume by facilitating Na+ absorption across transporting epithelia. In vitro studies showed that Cys-palmitoylation of the γENaC subunit is a major regulator of channel activity. We tested whether γ subunit palmitoylation sites are necessa...

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Bibliographic Details
Main Authors: Andrew J. Nickerson, Stephanie M. Mutchler, Shaohu Sheng, Natalie A. Cox, Evan C. Ray, Ossama B. Kashlan, Marcelo D. Carattino, Allison L. Marciszyn, Aaliyah Winfrey, Sebastien Gingras, Annet Kirabo, Rebecca P. Hughey, Thomas R. Kleyman
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-11-01
Series:JCI Insight
Subjects:
Cell biology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.172051

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