An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms9770 |
| _version_ | 1818855797288861696 |
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| author | Brad C. Bennett Michael D. Purdy Kent A. Baker Chayan Acharya William E. McIntire Raymond C. Stevens Qinghai Zhang Andrew L. Harris Ruben Abagyan Mark Yeager |
| author_facet | Brad C. Bennett Michael D. Purdy Kent A. Baker Chayan Acharya William E. McIntire Raymond C. Stevens Qinghai Zhang Andrew L. Harris Ruben Abagyan Mark Yeager |
| author_sort | Brad C. Bennett |
| collection | DOAJ |
| description | Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations. |
| first_indexed | 2024-12-19T08:14:19Z |
| format | Article |
| id | doaj.art-8711c8402a1e467da4c3721f1fe65a53 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:14:19Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8711c8402a1e467da4c3721f1fe65a532022-12-21T20:29:32ZengNature PortfolioNature Communications2041-17232016-01-017111210.1038/ncomms9770An electrostatic mechanism for Ca2+-mediated regulation of gap junction channelsBrad C. Bennett0Michael D. Purdy1Kent A. Baker2Chayan Acharya3William E. McIntire4Raymond C. Stevens5Qinghai Zhang6Andrew L. Harris7Ruben Abagyan8Mark Yeager9Department of Molecular Physiology and Biological Physics, University of Virginia School of MedicineDepartment of Molecular Physiology and Biological Physics, University of Virginia School of MedicineDepartment of Cell and Molecular Biology, The Scripps Research InstituteSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San DiegoDepartment of Pharmacology, University of Virginia School of MedicineDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern CaliforniaDepartment of Integrative Structural and Computational Biology, The Scripps Research InstituteDepartment of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical SchoolSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San DiegoDepartment of Molecular Physiology and Biological Physics, University of Virginia School of MedicineIntercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations.https://doi.org/10.1038/ncomms9770 |
| spellingShingle | Brad C. Bennett Michael D. Purdy Kent A. Baker Chayan Acharya William E. McIntire Raymond C. Stevens Qinghai Zhang Andrew L. Harris Ruben Abagyan Mark Yeager An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels Nature Communications |
| title | An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels |
| title_full | An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels |
| title_fullStr | An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels |
| title_full_unstemmed | An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels |
| title_short | An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels |
| title_sort | electrostatic mechanism for ca2 mediated regulation of gap junction channels |
| url | https://doi.org/10.1038/ncomms9770 |
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