An electrostatic mechanism for Ca2+-mediated regulation of gap junction channels
Intercellular signalling can be mediated by gap junction channels, and calcium blocks this signally during tissue injury. Here, the authors use X-ray crystallography and molecular dynamics to show that the calcium forms an electrostatic barrier to prevent transport of cations.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms9770 |