Treatment of echinococcosis: albendazole and mebendazole – what else?
The search for novel therapeutic options to cure alveolar echinococcosis (AE), due to the metacestode of Echinococcus multilocularis, is ongoing, and these developments could also have a profound impact on the treatment of cystic echinococcosis (CE), caused by the closely related Echinococcus granul...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2014-01-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/parasite/2014073 |
| _version_ | 1797430817786429440 |
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| author | Hemphill Andrew Stadelmann Britta Rufener Reto Spiliotis Markus Boubaker Ghalia Müller Joachim Müller Norbert Gorgas Daniela Gottstein Bruno |
| author_facet | Hemphill Andrew Stadelmann Britta Rufener Reto Spiliotis Markus Boubaker Ghalia Müller Joachim Müller Norbert Gorgas Daniela Gottstein Bruno |
| author_sort | Hemphill Andrew |
| collection | DOAJ |
| description | The search for novel therapeutic options to cure alveolar echinococcosis (AE), due to the metacestode of Echinococcus multilocularis, is ongoing, and these developments could also have a profound impact on the treatment of cystic echinococcosis (CE), caused by the closely related Echinococcus granulosus s.l. Several options are being explored. A viable strategy for the identification of novel chemotherapeutically valuable compounds includes whole-organism drug screening, employing large-scale in vitro metacestode cultures and, upon identification of promising compounds, verification of drug efficacy in small laboratory animals. Clearly, the current focus is targeted towards broad-spectrum anti-parasitic or anti-cancer drugs and compound classes that are already marketed, or that are in development for other applications. The availability of comprehensive Echinococcus genome information and gene expression data, as well as significant progress on the molecular level, has now opened the door for a more targeted drug discovery approach, which allows exploitation of defined pathways and enzymes that are essential for the parasite. In addition, current in vitro and in vivo models that are used to assess drug efficacy should be optimized and complemented by methods that give more detailed information on the host-parasite interactions that occur during drug treatments. The key to success is to identify, target and exploit those parasite molecules that orchestrate activities essential to parasite survival. |
| first_indexed | 2024-03-09T09:34:01Z |
| format | Article |
| id | doaj.art-8714c872808d489fbc40fb8bc92d2f44 |
| institution | Directory Open Access Journal |
| issn | 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T09:34:01Z |
| publishDate | 2014-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-8714c872808d489fbc40fb8bc92d2f442023-12-02T02:45:45ZengEDP SciencesParasite1776-10422014-01-01217010.1051/parasite/2014073parasite140072Treatment of echinococcosis: albendazole and mebendazole – what else?Hemphill AndrewStadelmann BrittaRufener RetoSpiliotis MarkusBoubaker GhaliaMüller JoachimMüller NorbertGorgas DanielaGottstein BrunoThe search for novel therapeutic options to cure alveolar echinococcosis (AE), due to the metacestode of Echinococcus multilocularis, is ongoing, and these developments could also have a profound impact on the treatment of cystic echinococcosis (CE), caused by the closely related Echinococcus granulosus s.l. Several options are being explored. A viable strategy for the identification of novel chemotherapeutically valuable compounds includes whole-organism drug screening, employing large-scale in vitro metacestode cultures and, upon identification of promising compounds, verification of drug efficacy in small laboratory animals. Clearly, the current focus is targeted towards broad-spectrum anti-parasitic or anti-cancer drugs and compound classes that are already marketed, or that are in development for other applications. The availability of comprehensive Echinococcus genome information and gene expression data, as well as significant progress on the molecular level, has now opened the door for a more targeted drug discovery approach, which allows exploitation of defined pathways and enzymes that are essential for the parasite. In addition, current in vitro and in vivo models that are used to assess drug efficacy should be optimized and complemented by methods that give more detailed information on the host-parasite interactions that occur during drug treatments. The key to success is to identify, target and exploit those parasite molecules that orchestrate activities essential to parasite survival.http://dx.doi.org/10.1051/parasite/2014073Alveolar echinococcosis (AE)Echinococcus multilocularis chemotherapyIn vitro cultureDrugsHost-parasite interaction |
| spellingShingle | Hemphill Andrew Stadelmann Britta Rufener Reto Spiliotis Markus Boubaker Ghalia Müller Joachim Müller Norbert Gorgas Daniela Gottstein Bruno Treatment of echinococcosis: albendazole and mebendazole – what else? Parasite Alveolar echinococcosis (AE) Echinococcus multilocularis chemotherapy In vitro culture Drugs Host-parasite interaction |
| title | Treatment of echinococcosis: albendazole and mebendazole – what else? |
| title_full | Treatment of echinococcosis: albendazole and mebendazole – what else? |
| title_fullStr | Treatment of echinococcosis: albendazole and mebendazole – what else? |
| title_full_unstemmed | Treatment of echinococcosis: albendazole and mebendazole – what else? |
| title_short | Treatment of echinococcosis: albendazole and mebendazole – what else? |
| title_sort | treatment of echinococcosis albendazole and mebendazole what else |
| topic | Alveolar echinococcosis (AE) Echinococcus multilocularis chemotherapy In vitro culture Drugs Host-parasite interaction |
| url | http://dx.doi.org/10.1051/parasite/2014073 |
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