Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study
Elderly people are at high risk of suffering from infection and being affected by severe forms of disease because their immunosystem suffers from aging. The alteration of normal immune functions causes the increase of pro-inflammatory cytokines which can expose these people to increased risk of deve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3476 |
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| author | Alessandro Maselli del Giudice Ignazio La Mantia Francesco Barbara Silvana Ciccarone Maria Sterpeta Ragno Valentina de Robertis Francesco Cariti Michele Barbara Luca D’Ascanio Arianna Di Stadio |
| author_facet | Alessandro Maselli del Giudice Ignazio La Mantia Francesco Barbara Silvana Ciccarone Maria Sterpeta Ragno Valentina de Robertis Francesco Cariti Michele Barbara Luca D’Ascanio Arianna Di Stadio |
| author_sort | Alessandro Maselli del Giudice |
| collection | DOAJ |
| description | Elderly people are at high risk of suffering from infection and being affected by severe forms of disease because their immunosystem suffers from aging. The alteration of normal immune functions causes the increase of pro-inflammatory cytokines which can expose these people to increased risk of developing pathologies as cancer, diabetes, and/or arthritis. Some supplements could be helpful for restoring normal immune functions. We conducted a case-control study to evaluate the efficacy of a supplement containing Sambucus nigra, zinc, tyndallized Lactobacillus acidophilus (HA122), arabinogalactans, vitamin D, vitamin E, and vitamin C to improve the inflammatory levels (IL-6 and CRP) and to modulate the lymphocytes growth. Additionally, we analyzed wellness by self-questionnaire. This study had two control group: a young group and an elderly one. Our study showed that treating elderly patients with the supplement for 30 days improved IL-6, CRP, and lymphocytes levels; the result was independent from the dosage of the supplements used. Elderly patients, despite the improvement, were not able to reach the same conditions of young patients; however, most of the patients (>70%) claimed to “feel better” after the use of the supplement. The use of this supplement should be considered at a low dosage for a prolonged period to reduce inflammation and modulate immune senescence in patients over 60 years old. |
| first_indexed | 2024-03-10T01:25:59Z |
| format | Article |
| id | doaj.art-8714cae9aada4256ae3039a83700ac10 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:25:59Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8714cae9aada4256ae3039a83700ac102023-11-23T13:51:02ZengMDPI AGNutrients2072-66432022-08-011417347610.3390/nu14173476Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control StudyAlessandro Maselli del Giudice0Ignazio La Mantia1Francesco Barbara2Silvana Ciccarone3Maria Sterpeta Ragno4Valentina de Robertis5Francesco Cariti6Michele Barbara7Luca D’Ascanio8Arianna Di Stadio9Department Otorhinolaryngology, Hospital of Barletta, 76121 Barletta (BT), ItalyDepartment GF Ingrassia, University of Catania, 95123 Catania, ItalyDepartment Otorhinolaryngology, University Hospital of Bari, 70126 Bari, ItalyDepartment Otorhinolaryngology, Hospital of Barletta, 76121 Barletta (BT), ItalyDepartment Otorhinolaryngology, Hospital of Barletta, 76121 Barletta (BT), ItalyDepartment Otorhinolaryngology, Hospital of Barletta, 76121 Barletta (BT), ItalyDepartment Otorhinolaryngology, Hospital of Barletta, 76121 Barletta (BT), ItalyDepartment Otorhinolaryngology, Hospital of Barletta, 76121 Barletta (BT), ItalyDepartment Otorhinolaryngology, Azienda Ospeliera Riunita Marche Nord (AORMN), 61032 Fano (PU), ItalyDepartment GF Ingrassia, University of Catania, 95123 Catania, ItalyElderly people are at high risk of suffering from infection and being affected by severe forms of disease because their immunosystem suffers from aging. The alteration of normal immune functions causes the increase of pro-inflammatory cytokines which can expose these people to increased risk of developing pathologies as cancer, diabetes, and/or arthritis. Some supplements could be helpful for restoring normal immune functions. We conducted a case-control study to evaluate the efficacy of a supplement containing Sambucus nigra, zinc, tyndallized Lactobacillus acidophilus (HA122), arabinogalactans, vitamin D, vitamin E, and vitamin C to improve the inflammatory levels (IL-6 and CRP) and to modulate the lymphocytes growth. Additionally, we analyzed wellness by self-questionnaire. This study had two control group: a young group and an elderly one. Our study showed that treating elderly patients with the supplement for 30 days improved IL-6, CRP, and lymphocytes levels; the result was independent from the dosage of the supplements used. Elderly patients, despite the improvement, were not able to reach the same conditions of young patients; however, most of the patients (>70%) claimed to “feel better” after the use of the supplement. The use of this supplement should be considered at a low dosage for a prolonged period to reduce inflammation and modulate immune senescence in patients over 60 years old.https://www.mdpi.com/2072-6643/14/17/3476immuno-senescenceoral supplementinflammatory cytokinesagingzincvitamin D |
| spellingShingle | Alessandro Maselli del Giudice Ignazio La Mantia Francesco Barbara Silvana Ciccarone Maria Sterpeta Ragno Valentina de Robertis Francesco Cariti Michele Barbara Luca D’Ascanio Arianna Di Stadio Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study Nutrients immuno-senescence oral supplement inflammatory cytokines aging zinc vitamin D |
| title | Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study |
| title_full | Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study |
| title_fullStr | Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study |
| title_full_unstemmed | Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study |
| title_short | Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study |
| title_sort | use of nutraceuticals in elderly to fight inflammation and immuno senescence a randomized case control study |
| topic | immuno-senescence oral supplement inflammatory cytokines aging zinc vitamin D |
| url | https://www.mdpi.com/2072-6643/14/17/3476 |
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