Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline
Mutations in the p53 gene are the most frequently observed genetic lesions in human cancers. Human cancers that contain a p53 mutation are more aggressive, more apt to metastasize, and more often fatal. p53 controls numerous downstream targets that can influence various outcomes such as apoptosis, g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2004-10-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1162/15353500200404121 |
| _version_ | 1826910933121761280 |
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| author | Noriko Mori Robert Delsite Kshama Natarajan Mariola Kulawiec Zaver M. Bhujwalla Keshav K. Singh |
| author_facet | Noriko Mori Robert Delsite Kshama Natarajan Mariola Kulawiec Zaver M. Bhujwalla Keshav K. Singh |
| author_sort | Noriko Mori |
| collection | DOAJ |
| description | Mutations in the p53 gene are the most frequently observed genetic lesions in human cancers. Human cancers that contain a p53 mutation are more aggressive, more apt to metastasize, and more often fatal. p53 controls numerous downstream targets that can influence various outcomes such as apoptosis, growth arrest, and DNA repair. Based on previous observations using 1 H magnetic resonance spectroscopy (MRS), we have identified choline phospholipid metabolite intensities typical of increased malignancy. Here we have used 1 H MRS to characterize the choline phospholipid metabolite levels of p53 +/+ and p53 −/– cells, and demonstrated that loss of p53 function results in increased phosphocholine and total choline. These data suggest that the increased malignancy of cancer cells resulting from loss of p53 may be mediated, in part, through the choline phospholipid pathway. |
| first_indexed | 2024-03-07T17:59:49Z |
| format | Article |
| id | doaj.art-871514f9ed05415493d93ce7befbe797 |
| institution | Directory Open Access Journal |
| issn | 1536-0121 |
| language | English |
| last_indexed | 2025-02-17T10:07:15Z |
| publishDate | 2004-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj.art-871514f9ed05415493d93ce7befbe7972025-01-02T02:58:54ZengSAGE PublishingMolecular Imaging1536-01212004-10-01310.1162/1535350020040412110.1162_15353500200404121Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total CholineNoriko Mori0Robert Delsite1Kshama Natarajan2Mariola Kulawiec3Zaver M. Bhujwalla4Keshav K. Singh5The Johns Hopkins University School of MedicineThe Johns Hopkins University School of MedicineThe Johns Hopkins University School of MedicineThe Johns Hopkins University School of MedicineThe Johns Hopkins University School of MedicineRoswell Park Cancer InstituteMutations in the p53 gene are the most frequently observed genetic lesions in human cancers. Human cancers that contain a p53 mutation are more aggressive, more apt to metastasize, and more often fatal. p53 controls numerous downstream targets that can influence various outcomes such as apoptosis, growth arrest, and DNA repair. Based on previous observations using 1 H magnetic resonance spectroscopy (MRS), we have identified choline phospholipid metabolite intensities typical of increased malignancy. Here we have used 1 H MRS to characterize the choline phospholipid metabolite levels of p53 +/+ and p53 −/– cells, and demonstrated that loss of p53 function results in increased phosphocholine and total choline. These data suggest that the increased malignancy of cancer cells resulting from loss of p53 may be mediated, in part, through the choline phospholipid pathway.https://doi.org/10.1162/15353500200404121 |
| spellingShingle | Noriko Mori Robert Delsite Kshama Natarajan Mariola Kulawiec Zaver M. Bhujwalla Keshav K. Singh Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline Molecular Imaging |
| title | Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline |
| title_full | Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline |
| title_fullStr | Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline |
| title_full_unstemmed | Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline |
| title_short | Loss of P53 Function in Colon Cancer Cells Results in Increased Phosphocholine and Total Choline |
| title_sort | loss of p53 function in colon cancer cells results in increased phosphocholine and total choline |
| url | https://doi.org/10.1162/15353500200404121 |
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