Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019
(1) Background: The primary objective of this study was to examine the rate of genetic referral, BRCA testing, and BRCA positivity amongst all patients with high-grade serous ovarian cancers (HGSOC) from 2004–2019. The secondary objective was to analyze secondary factors that may affect the rates of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/12/735 |
| _version_ | 1797460747780882432 |
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| author | Kelcey Winchar Pascal Lambert Kirk J. McManus Bernie Chodirker Sarah Kean Kim Serfas Kathleen Decker Mark W. Nachtigal Alon D. Altman |
| author_facet | Kelcey Winchar Pascal Lambert Kirk J. McManus Bernie Chodirker Sarah Kean Kim Serfas Kathleen Decker Mark W. Nachtigal Alon D. Altman |
| author_sort | Kelcey Winchar |
| collection | DOAJ |
| description | (1) Background: The primary objective of this study was to examine the rate of genetic referral, BRCA testing, and BRCA positivity amongst all patients with high-grade serous ovarian cancers (HGSOC) from 2004–2019. The secondary objective was to analyze secondary factors that may affect the rates of referral and testing. (2) Methods: This population-based cohort study included all women diagnosed with HGSOC using the Manitoba Cancer Registry, CervixCheck registry, <i>Medical Claims</i> database at Manitoba Health, the Hospital Discharge abstract, the Population Registry, and Winnipeg Regional Health Authority genetics data. Data were examined for three different time cohorts (2004–2013, 2014–2016; 2017–2019) correlating to practice pattern changes. (3) Results: A total of 944 patients were diagnosed with HGSOC. The rate of genetic referrals changed over the three timeframes (20.0% → 56.7% → 36.6%) and rate of genetic testing increased over the entire timeframe. Factors found to increase rates of referral and testing included age, histology, history of oral contraceptive use, and family history of ovarian cancer. Prior health care utilization indicators did not affect genetic referral or testing. (4) Conclusion: The rate of genetic referral (2004–2016) and <i>BRCA1/2</i> testing (2004–2019) for patients with a diagnosis of HGSOC increased over time. A minority of patients received a consultation for genetics counselling, and even fewer received testing for a <i>BRCA1/2</i>. Without a genetic result, it is difficult for clinicians to inform treatment decisions. Additional efforts are needed to increase genetics consultation and testing for Manitoban patients with HGSOC. Effects of routine tumour testing on rates of genetic referral will have to be examined in future studies. |
| first_indexed | 2024-03-09T17:09:28Z |
| format | Article |
| id | doaj.art-87167dc5edf64399bbd50c4464f0103c |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T17:09:28Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-87167dc5edf64399bbd50c4464f0103c2023-11-24T14:12:38ZengMDPI AGCurrent Oncology1198-00521718-77292022-11-0129129365937610.3390/curroncol29120735Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019Kelcey Winchar0Pascal Lambert1Kirk J. McManus2Bernie Chodirker3Sarah Kean4Kim Serfas5Kathleen Decker6Mark W. Nachtigal7Alon D. Altman8Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, CanadaCancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E OV9, CanadaCancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E OV9, CanadaBiochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB R3E OV9, CanadaObstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, CanadaBiochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB R3E OV9, CanadaCancerCare Manitoba Research Institute, CancerCare Manitoba, Winnipeg, MB R3E OV9, CanadaObstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, CanadaObstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, MB R3A 1R9, Canada(1) Background: The primary objective of this study was to examine the rate of genetic referral, BRCA testing, and BRCA positivity amongst all patients with high-grade serous ovarian cancers (HGSOC) from 2004–2019. The secondary objective was to analyze secondary factors that may affect the rates of referral and testing. (2) Methods: This population-based cohort study included all women diagnosed with HGSOC using the Manitoba Cancer Registry, CervixCheck registry, <i>Medical Claims</i> database at Manitoba Health, the Hospital Discharge abstract, the Population Registry, and Winnipeg Regional Health Authority genetics data. Data were examined for three different time cohorts (2004–2013, 2014–2016; 2017–2019) correlating to practice pattern changes. (3) Results: A total of 944 patients were diagnosed with HGSOC. The rate of genetic referrals changed over the three timeframes (20.0% → 56.7% → 36.6%) and rate of genetic testing increased over the entire timeframe. Factors found to increase rates of referral and testing included age, histology, history of oral contraceptive use, and family history of ovarian cancer. Prior health care utilization indicators did not affect genetic referral or testing. (4) Conclusion: The rate of genetic referral (2004–2016) and <i>BRCA1/2</i> testing (2004–2019) for patients with a diagnosis of HGSOC increased over time. A minority of patients received a consultation for genetics counselling, and even fewer received testing for a <i>BRCA1/2</i>. Without a genetic result, it is difficult for clinicians to inform treatment decisions. Additional efforts are needed to increase genetics consultation and testing for Manitoban patients with HGSOC. Effects of routine tumour testing on rates of genetic referral will have to be examined in future studies.https://www.mdpi.com/1718-7729/29/12/735BRCAgenetic testinggenetic referralhigh-grade serous ovarian cancer |
| spellingShingle | Kelcey Winchar Pascal Lambert Kirk J. McManus Bernie Chodirker Sarah Kean Kim Serfas Kathleen Decker Mark W. Nachtigal Alon D. Altman Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019 Current Oncology BRCA genetic testing genetic referral high-grade serous ovarian cancer |
| title | Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019 |
| title_full | Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019 |
| title_fullStr | Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019 |
| title_full_unstemmed | Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019 |
| title_short | Referral, Genetic Counselling, and <i>BRCA</i> Testing in the Manitoba High-Grade Serous Ovarian Cancer Population, 2004–2019 |
| title_sort | referral genetic counselling and i brca i testing in the manitoba high grade serous ovarian cancer population 2004 2019 |
| topic | BRCA genetic testing genetic referral high-grade serous ovarian cancer |
| url | https://www.mdpi.com/1718-7729/29/12/735 |
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