Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis
Influenza endangers human health but can be prevented in part by vaccination. Assessing influenza vaccine effectiveness (VE) provides scientific evidence for developing influenza vaccination policy. We conducted a systematic review and meta-analysis of studies that evaluated influenza VE in mainland...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/2/79 |
| _version_ | 1797408038833881088 |
|---|---|
| author | Xiaokun Yang Hongting Zhao Zhili Li Aiqin Zhu Minrui Ren Mengjie Geng Yu Li Ying Qin Luzhao Feng Zhibin Peng Zhijie An Jiandong Zheng Zhongjie Li Zijian Feng |
| author_facet | Xiaokun Yang Hongting Zhao Zhili Li Aiqin Zhu Minrui Ren Mengjie Geng Yu Li Ying Qin Luzhao Feng Zhibin Peng Zhijie An Jiandong Zheng Zhongjie Li Zijian Feng |
| author_sort | Xiaokun Yang |
| collection | DOAJ |
| description | Influenza endangers human health but can be prevented in part by vaccination. Assessing influenza vaccine effectiveness (VE) provides scientific evidence for developing influenza vaccination policy. We conducted a systematic review and meta-analysis of studies that evaluated influenza VE in mainland China. We searched six relevant databases as of 30 August 2019 to identify studies and used Review Manager 5.3 software to analyze the included studies. The Newcastle–Ottawa scale was used to assess the risk of publication bias. We identified 1408 publications, and after removing duplicates and screening full texts, we included 21 studies in the analyses. Studies were conducted in Beijing, Guangzhou, Suzhou, and Zhejiang province from the 2010/11 influenza season through the 2017/18 influenza season. Overall influenza VE for laboratory confirmed influenza was 36% (95% CI: 25–46%). In the subgroup analysis, VE was 45% (95% CI: 18–64%) for children 6–35 months who received one dose of influenza vaccine, and 57% (95% CI: 50–64%) who received two doses. VE was 47% (95% CI: 39–54%) for children 6 months to 8 years, and 18% (95% CI: 0–33%) for adults ≥60 years. For inpatients, VE was 21% (95% CI: −11–44%). We conclude that influenza vaccines that were used in mainland China had a moderate effectiveness, with VE being higher among children than the elderly. Influenza VE should be continuously monitored in mainland China to provide evidence for policy making and improving uptake of the influenza vaccine. |
| first_indexed | 2024-03-09T03:52:33Z |
| format | Article |
| id | doaj.art-8718ce2d0367469e85e0fe10d27542ef |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T03:52:33Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-8718ce2d0367469e85e0fe10d27542ef2023-12-03T14:25:55ZengMDPI AGVaccines2076-393X2021-01-01927910.3390/vaccines9020079Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-AnalysisXiaokun Yang0Hongting Zhao1Zhili Li2Aiqin Zhu3Minrui Ren4Mengjie Geng5Yu Li6Ying Qin7Luzhao Feng8Zhibin Peng9Zhijie An10Jiandong Zheng11Zhongjie Li12Zijian Feng13Division of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease Prevention and Disinfection Management, Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDivision of Infectious Disease, Key Laboratory of Surveillance and Early-Warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaChinese Center for Disease Control and Prevention, Beijing 102206, ChinaInfluenza endangers human health but can be prevented in part by vaccination. Assessing influenza vaccine effectiveness (VE) provides scientific evidence for developing influenza vaccination policy. We conducted a systematic review and meta-analysis of studies that evaluated influenza VE in mainland China. We searched six relevant databases as of 30 August 2019 to identify studies and used Review Manager 5.3 software to analyze the included studies. The Newcastle–Ottawa scale was used to assess the risk of publication bias. We identified 1408 publications, and after removing duplicates and screening full texts, we included 21 studies in the analyses. Studies were conducted in Beijing, Guangzhou, Suzhou, and Zhejiang province from the 2010/11 influenza season through the 2017/18 influenza season. Overall influenza VE for laboratory confirmed influenza was 36% (95% CI: 25–46%). In the subgroup analysis, VE was 45% (95% CI: 18–64%) for children 6–35 months who received one dose of influenza vaccine, and 57% (95% CI: 50–64%) who received two doses. VE was 47% (95% CI: 39–54%) for children 6 months to 8 years, and 18% (95% CI: 0–33%) for adults ≥60 years. For inpatients, VE was 21% (95% CI: −11–44%). We conclude that influenza vaccines that were used in mainland China had a moderate effectiveness, with VE being higher among children than the elderly. Influenza VE should be continuously monitored in mainland China to provide evidence for policy making and improving uptake of the influenza vaccine.https://www.mdpi.com/2076-393X/9/2/79influenzavaccine effectivenessChinasystematic reviewmeta-analysis |
| spellingShingle | Xiaokun Yang Hongting Zhao Zhili Li Aiqin Zhu Minrui Ren Mengjie Geng Yu Li Ying Qin Luzhao Feng Zhibin Peng Zhijie An Jiandong Zheng Zhongjie Li Zijian Feng Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis Vaccines influenza vaccine effectiveness China systematic review meta-analysis |
| title | Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis |
| title_full | Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis |
| title_fullStr | Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis |
| title_short | Influenza Vaccine Effectiveness in Mainland China: A Systematic Review and Meta-Analysis |
| title_sort | influenza vaccine effectiveness in mainland china a systematic review and meta analysis |
| topic | influenza vaccine effectiveness China systematic review meta-analysis |
| url | https://www.mdpi.com/2076-393X/9/2/79 |
| work_keys_str_mv | AT xiaokunyang influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT hongtingzhao influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT zhilili influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT aiqinzhu influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT minruiren influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT mengjiegeng influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT yuli influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT yingqin influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT luzhaofeng influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT zhibinpeng influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT zhijiean influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT jiandongzheng influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT zhongjieli influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis AT zijianfeng influenzavaccineeffectivenessinmainlandchinaasystematicreviewandmetaanalysis |