Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy
Background: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. Aim: The aim of this stud...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-02-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | http://dx.doi.org/10.1080/09546634.2017.1357797 |
| _version_ | 1797683748914855936 |
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| author | Marta Wacewicz Katarzyna Socha Jolanta Soroczyńska Marek Niczyporuk Piotr Aleksiejczuk Jolanta Ostrowska Maria H. Borawska |
| author_facet | Marta Wacewicz Katarzyna Socha Jolanta Soroczyńska Marek Niczyporuk Piotr Aleksiejczuk Jolanta Ostrowska Maria H. Borawska |
| author_sort | Marta Wacewicz |
| collection | DOAJ |
| description | Background: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. Aim: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo. Methods: We assessed 50 patients with vitiligo and 58 healthy controls. Serum levels of Se, Zn and Cu were determined by the atomic absorption spectrometry method, and the Cu/Zn ratio was also calculated. TAS in serum was measured spectrophotometrically. Result: Serum concentration of Se in patients with vitiligo before and after phototherapy was significantly lower as compared to the control group. Zn level in the serum of patients decreased significantly after phototherapy. We observed higher Cu/Zn ratio (p < .05) in examined patients than in the control group and after NB-UVB. We have found decrease in TAS in the serum of vitiligo patients after NB-UVB. Conclusions: The current study showed some disturbances in the serum levels of trace elements and total antioxidant status in vitiligo patients. |
| first_indexed | 2024-03-12T00:19:18Z |
| format | Article |
| id | doaj.art-871913ee7663473ea06516d357beda40 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:19:18Z |
| publishDate | 2018-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-871913ee7663473ea06516d357beda402023-09-15T14:08:31ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532018-02-0129219019510.1080/09546634.2017.13577971357797Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapyMarta Wacewicz0Katarzyna Socha1Jolanta Soroczyńska2Marek Niczyporuk3Piotr Aleksiejczuk4Jolanta Ostrowska5Maria H. Borawska6Medical University of BialystokMedical University of BialystokMedical University of BialystokMedical University of BialystokMedical University of Bialystok, Clinical HospitalMedical University of Bialystok, Clinical HospitalMedical University of BialystokBackground: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. Aim: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo. Methods: We assessed 50 patients with vitiligo and 58 healthy controls. Serum levels of Se, Zn and Cu were determined by the atomic absorption spectrometry method, and the Cu/Zn ratio was also calculated. TAS in serum was measured spectrophotometrically. Result: Serum concentration of Se in patients with vitiligo before and after phototherapy was significantly lower as compared to the control group. Zn level in the serum of patients decreased significantly after phototherapy. We observed higher Cu/Zn ratio (p < .05) in examined patients than in the control group and after NB-UVB. We have found decrease in TAS in the serum of vitiligo patients after NB-UVB. Conclusions: The current study showed some disturbances in the serum levels of trace elements and total antioxidant status in vitiligo patients.http://dx.doi.org/10.1080/09546634.2017.1357797vitiligonarrow band ultraviolet-b phototherapyseleniumzinccoppertotal antioxidant status |
| spellingShingle | Marta Wacewicz Katarzyna Socha Jolanta Soroczyńska Marek Niczyporuk Piotr Aleksiejczuk Jolanta Ostrowska Maria H. Borawska Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy Journal of Dermatological Treatment vitiligo narrow band ultraviolet-b phototherapy selenium zinc copper total antioxidant status |
| title | Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy |
| title_full | Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy |
| title_fullStr | Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy |
| title_full_unstemmed | Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy |
| title_short | Selenium, zinc, copper, Cu/Zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow-band ultraviolet-B phototherapy |
| title_sort | selenium zinc copper cu zn ratio and total antioxidant status in the serum of vitiligo patients treated by narrow band ultraviolet b phototherapy |
| topic | vitiligo narrow band ultraviolet-b phototherapy selenium zinc copper total antioxidant status |
| url | http://dx.doi.org/10.1080/09546634.2017.1357797 |
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