Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells

Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells

Bone morphogenetic protein (BMP) and Notch signaling are critical for endothelial cell (EC) differentiation in vascular development. Recent studies have shown that excess BMP activity induces Notch signaling in cerebral ECs resulting in arteriovenous malformation (AVMs). However, it is unclear how t...

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Bibliographic Details
Main Authors: Xiuju Wu, Jiayi Yao, Lumin Wang, Daoqin Zhang, Li Zhang, Eric X. Reynolds, Tongtong Yu, Kristina I. Boström, Yucheng Yao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
Sox2
bone morphogenetic protein
Notch
endothelial cells
Online Access:https://www.mdpi.com/2073-4409/8/6/549

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