Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells

Identification of pAKT as a pharmacodynamic marker for MER kinase in human melanoma G361 cells

Abstract Background The MER signaling pathway represents an attractive therapeutic target for human cancers. Growth arrest–specific protein 6 (GAS6)–induced MER phosphorylation is often unstable and difficult to detect without pervanadate pretreatment in human cancer cells, posing a challenge for th...

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Bibliographic Details
Main Authors: Yaoyu Chen, Margaret Favata, Michelle Pusey, Jun Li, Yvonne Lo, Min Ye, Richard Wynn, Xiaozhao Wang, Wenqing Yao, Yingnan Chen
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Biomarker Research
Subjects:
Biomarker
MER kinase
Phosphorylated AKT
Online Access:https://doi.org/10.1186/s40364-020-0184-9

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