Alteration of adeS Contributes to Tigecycline Resistance and Collateral Sensitivity to Sulbactam in Acinetobacter baumannii

Alteration of adeS Contributes to Tigecycline Resistance and Collateral Sensitivity to Sulbactam in Acinetobacter baumannii

ABSTRACT The treatment of extensively drug-resistant (XDR) A. baumannii has emerged as a major problem. Tigecycline (TGC) and sulbactam (SUL) are both effective antibiotics against XDR A. baumannii. Here, we investigated the in-host evolution and mechanism of collateral sensitivity (CS) phenomenon i...

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Bibliographic Details
Main Authors: Yunxing Yang, Xiaochen Liu, Danyan Zhou, Jintao He, Qiong Chen, Qingye Xu, Shenghai Wu, Weiying Zhang, Yue Yao, Ying Fu, Xiaoting Hua, Yunsong Yu, Xianjun Wang
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
Acinetobacter baumannii
adeS
collateral sensitivity
tigecycline
sulbactam
seesaw effect
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04594-22

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