Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure
Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/2/441 |
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| author | Madelaine Eloranta Rossholt Kristina Wendel Marianne Bratlie Marlen Fossan Aas Gunnthorunn Gunnarsdottir Drude Fugelseth Are Hugo Pripp Magnus Domellöf Ketil Størdal Tom Stiris Sissel Jennifer Moltu |
| author_facet | Madelaine Eloranta Rossholt Kristina Wendel Marianne Bratlie Marlen Fossan Aas Gunnthorunn Gunnarsdottir Drude Fugelseth Are Hugo Pripp Magnus Domellöf Ketil Størdal Tom Stiris Sissel Jennifer Moltu |
| author_sort | Madelaine Eloranta Rossholt |
| collection | DOAJ |
| description | Vitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A concentrations in blood. We report detailed information on vitamin A biochemistry, vitamin A intake, markers of inflammation and dexamethasone exposure. After four weeks of age, infants exposed to dexamethasone (<i>n</i> = 39) showed higher vitamin A concentrations compared to unexposed infants (<i>n</i> = 41); median (IQR) retinol was 1.0 (0.74, 1.5) vs. 0.56 (0.41, 0.74) µmol/L, <i>p</i> < 0.001. Pretreatment retinol concentrations were lower in the dexamethasone group compared to non-exposed infants (<i>p</i> < 0.001); 88% vs. 60% of the infants were considered deficient in vitamin A (retinol < 0.7 µmol/L) at one week of age. Small size for gestational age, mechanical ventilation and elevated levels of interleukin-6 were factors negatively associated with first-week retinol concentrations. In conclusion, preterm infants <29 weeks gestation are at risk of vitamin A deficiency despite intakes that accommodate current recommendations. The presence of inflammation and dexamethasone exposure should be considered when interpreting vitamin A status. |
| first_indexed | 2024-03-09T11:30:40Z |
| format | Article |
| id | doaj.art-8729bf33b91042cfb7246c57546ce443 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:30:40Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8729bf33b91042cfb7246c57546ce4432023-11-30T23:51:48ZengMDPI AGNutrients2072-66432023-01-0115244110.3390/nu15020441Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone ExposureMadelaine Eloranta Rossholt0Kristina Wendel1Marianne Bratlie2Marlen Fossan Aas3Gunnthorunn Gunnarsdottir4Drude Fugelseth5Are Hugo Pripp6Magnus Domellöf7Ketil Størdal8Tom Stiris9Sissel Jennifer Moltu10Department of Neonatal Intensive Care, Oslo University Hospital, 0450 Oslo, NorwayDepartment of Neonatal Intensive Care, Oslo University Hospital, 0450 Oslo, NorwayDepartment of Pediatrics and Adolescence Medicine, Oslo University Hospital, 0450 Oslo, NorwayDepartment of Neonatal Intensive Care, Oslo University Hospital, 0450 Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, 0450 Oslo, NorwayDepartment of Neonatal Intensive Care, Oslo University Hospital, 0450 Oslo, NorwayOslo Centre of Biostatistics and Epidemiology, Oslo University Hospital, 0450 Oslo, NorwayDepartment of Clinical Sciences, Pediatrics, Umeå University, 901 87 Umea, SwedenDepartment of Pediatrics and Adolescence Medicine, Oslo University Hospital, 0450 Oslo, NorwayDepartment of Neonatal Intensive Care, Oslo University Hospital, 0450 Oslo, NorwayDepartment of Neonatal Intensive Care, Oslo University Hospital, 0450 Oslo, NorwayVitamin A has a key role in lung development and its deficiency is associated with an increased risk of bronchopulmonary dysplasia. This secondary cohort analysis of the ImNuT trial (Immature, Nutrition Therapy NCT03555019) aimed to (1) explore vitamin A status in preterm infants <29 weeks gestation and (2) assess the influence of inflammation and postnatal dexamethasone exposure on vitamin A concentrations in blood. We report detailed information on vitamin A biochemistry, vitamin A intake, markers of inflammation and dexamethasone exposure. After four weeks of age, infants exposed to dexamethasone (<i>n</i> = 39) showed higher vitamin A concentrations compared to unexposed infants (<i>n</i> = 41); median (IQR) retinol was 1.0 (0.74, 1.5) vs. 0.56 (0.41, 0.74) µmol/L, <i>p</i> < 0.001. Pretreatment retinol concentrations were lower in the dexamethasone group compared to non-exposed infants (<i>p</i> < 0.001); 88% vs. 60% of the infants were considered deficient in vitamin A (retinol < 0.7 µmol/L) at one week of age. Small size for gestational age, mechanical ventilation and elevated levels of interleukin-6 were factors negatively associated with first-week retinol concentrations. In conclusion, preterm infants <29 weeks gestation are at risk of vitamin A deficiency despite intakes that accommodate current recommendations. The presence of inflammation and dexamethasone exposure should be considered when interpreting vitamin A status.https://www.mdpi.com/2072-6643/15/2/441vitamin Apreterm infantdexamethasoneinflammationbronchopulmonary dysplasia |
| spellingShingle | Madelaine Eloranta Rossholt Kristina Wendel Marianne Bratlie Marlen Fossan Aas Gunnthorunn Gunnarsdottir Drude Fugelseth Are Hugo Pripp Magnus Domellöf Ketil Størdal Tom Stiris Sissel Jennifer Moltu Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure Nutrients vitamin A preterm infant dexamethasone inflammation bronchopulmonary dysplasia |
| title | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
| title_full | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
| title_fullStr | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
| title_full_unstemmed | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
| title_short | Vitamin A Status in Preterm Infants Is Associated with Inflammation and Dexamethasone Exposure |
| title_sort | vitamin a status in preterm infants is associated with inflammation and dexamethasone exposure |
| topic | vitamin A preterm infant dexamethasone inflammation bronchopulmonary dysplasia |
| url | https://www.mdpi.com/2072-6643/15/2/441 |
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