Gut microbiota derived metabolites in cardiovascular health and disease
ABSTRACT Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2018-05-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-018-0549-0 |
| _version_ | 1797708268906217472 |
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| author | Zeneng Wang Yongzhong Zhao |
| author_facet | Zeneng Wang Yongzhong Zhao |
| author_sort | Zeneng Wang |
| collection | DOAJ |
| description | ABSTRACT Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A better understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and precise interventions. |
| first_indexed | 2024-03-12T06:18:51Z |
| format | Article |
| id | doaj.art-872be2f8c0254ff5b24d1c33b3045351 |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T06:18:51Z |
| publishDate | 2018-05-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-872be2f8c0254ff5b24d1c33b30453512023-09-03T02:21:48ZengOxford University PressProtein & Cell1674-800X1674-80182018-05-019541643110.1007/s13238-018-0549-0Gut microbiota derived metabolites in cardiovascular health and diseaseZeneng Wang0Yongzhong Zhao1Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland ClinicABSTRACT Trillions of microbes inhabit the human gut, not only providing nutrients and energy to the host from the ingested food, but also producing metabolic bioactive signaling molecules to maintain health and elicit disease, such as cardiovascular disease (CVD). CVD is the leading cause of mortality worldwide. In this review, we presented gut microbiota derived metabolites involved in cardiovascular health and disease, including trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids and lipopolysaccharide. These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A better understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and precise interventions.http://link.springer.com/article/10.1007/s13238-018-0549-0gut microbiotametabolitescardiovascular healthcardiovascular disease |
| spellingShingle | Zeneng Wang Yongzhong Zhao Gut microbiota derived metabolites in cardiovascular health and disease Protein & Cell gut microbiota metabolites cardiovascular health cardiovascular disease |
| title | Gut microbiota derived metabolites in cardiovascular health and disease |
| title_full | Gut microbiota derived metabolites in cardiovascular health and disease |
| title_fullStr | Gut microbiota derived metabolites in cardiovascular health and disease |
| title_full_unstemmed | Gut microbiota derived metabolites in cardiovascular health and disease |
| title_short | Gut microbiota derived metabolites in cardiovascular health and disease |
| title_sort | gut microbiota derived metabolites in cardiovascular health and disease |
| topic | gut microbiota metabolites cardiovascular health cardiovascular disease |
| url | http://link.springer.com/article/10.1007/s13238-018-0549-0 |
| work_keys_str_mv | AT zenengwang gutmicrobiotaderivedmetabolitesincardiovascularhealthanddisease AT yongzhongzhao gutmicrobiotaderivedmetabolitesincardiovascularhealthanddisease |