Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels
Objective: Psoriasis has been considered as systemic disorder. Lipocalin-2 might be a link between psoriasis and its comorbidities. Aim of the study was to investigate the associations between serum lipocalin-2 levels and the disease activity, markers of inflammation or metabolic disturbances and ch...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-02-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2016.1180340 |
| _version_ | 1797684011252842496 |
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| author | A. Baran M. Świderska H. Myśliwiec I. Flisiak |
| author_facet | A. Baran M. Świderska H. Myśliwiec I. Flisiak |
| author_sort | A. Baran |
| collection | DOAJ |
| description | Objective: Psoriasis has been considered as systemic disorder. Lipocalin-2 might be a link between psoriasis and its comorbidities. Aim of the study was to investigate the associations between serum lipocalin-2 levels and the disease activity, markers of inflammation or metabolic disturbances and changes after topical treatment in psoriatic patients. Methods: Thirty-seven individuals with active plaque-type psoriasis and 15 healthy controls were recruited. Blood samples were collected before and after 14 days of therapy. Serum lipocalin-2 concentrations were examined by enzyme-linked immunosorbent assay. The results were correlated with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory and biochemical markers, lipid profile and with effectiveness of topical treatment. Results: Lipocalin-2 serum levels were significantly increased in psoriatic patients in comparison to the controls (p = 0.023). No significant correlations with indicators of inflammation, nor BMI or PASI were noted. A statistical association between lipocalin-2 and low-density lipoprotein-cholesterol was shown. After topical treatment serum lipocalin-2 level did not significantly change (p = 0.9), still remaining higher than in the controls, despite clinical improvement. Conclusions: Lipocalin-2 might be a marker of psoriasis and convey cardiovascular or metabolic risk in psoriatic patients, but may not be a reliable indicator of inflammation, severity of psoriasis nor efficacy of antipsoriatic treatment. |
| first_indexed | 2024-03-12T00:23:10Z |
| format | Article |
| id | doaj.art-872df1645a074242af11c19c3efec49e |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:23:10Z |
| publishDate | 2017-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-872df1645a074242af11c19c3efec49e2023-09-15T10:48:02ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532017-02-0128213614010.1080/09546634.2016.11803401180340Effect of psoriasis activity and topical treatment on serum lipocalin-2 levelsA. Baran0M. Świderska1H. Myśliwiec2I. Flisiak3Medical University of BialystokMedical University of BialystokMedical University of BialystokMedical University of BialystokObjective: Psoriasis has been considered as systemic disorder. Lipocalin-2 might be a link between psoriasis and its comorbidities. Aim of the study was to investigate the associations between serum lipocalin-2 levels and the disease activity, markers of inflammation or metabolic disturbances and changes after topical treatment in psoriatic patients. Methods: Thirty-seven individuals with active plaque-type psoriasis and 15 healthy controls were recruited. Blood samples were collected before and after 14 days of therapy. Serum lipocalin-2 concentrations were examined by enzyme-linked immunosorbent assay. The results were correlated with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory and biochemical markers, lipid profile and with effectiveness of topical treatment. Results: Lipocalin-2 serum levels were significantly increased in psoriatic patients in comparison to the controls (p = 0.023). No significant correlations with indicators of inflammation, nor BMI or PASI were noted. A statistical association between lipocalin-2 and low-density lipoprotein-cholesterol was shown. After topical treatment serum lipocalin-2 level did not significantly change (p = 0.9), still remaining higher than in the controls, despite clinical improvement. Conclusions: Lipocalin-2 might be a marker of psoriasis and convey cardiovascular or metabolic risk in psoriatic patients, but may not be a reliable indicator of inflammation, severity of psoriasis nor efficacy of antipsoriatic treatment.http://dx.doi.org/10.1080/09546634.2016.1180340psoriasislipocalin-2adipokinestopical treatmentanthralin |
| spellingShingle | A. Baran M. Świderska H. Myśliwiec I. Flisiak Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels Journal of Dermatological Treatment psoriasis lipocalin-2 adipokines topical treatment anthralin |
| title | Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels |
| title_full | Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels |
| title_fullStr | Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels |
| title_full_unstemmed | Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels |
| title_short | Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels |
| title_sort | effect of psoriasis activity and topical treatment on serum lipocalin 2 levels |
| topic | psoriasis lipocalin-2 adipokines topical treatment anthralin |
| url | http://dx.doi.org/10.1080/09546634.2016.1180340 |
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