High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand
Silada Kanokrungsee, Chanikarn Patcharapojanart, Poonkiat Suchonwanit, Kumutnart Chanprapaph Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kumutnart Chanprapaph, Division of Dermatology, Department of...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/high-prevalence-of-hypovitaminosis-d-in-cutaneous-and-systemic-lupus-e-peer-reviewed-fulltext-article-CCID |
| _version_ | 1818497233626071040 |
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| author | Kanokrungsee S Patcharapojanart C Suchonwanit P Chanprapaph K |
| author_facet | Kanokrungsee S Patcharapojanart C Suchonwanit P Chanprapaph K |
| author_sort | Kanokrungsee S |
| collection | DOAJ |
| description | Silada Kanokrungsee, Chanikarn Patcharapojanart, Poonkiat Suchonwanit, Kumutnart Chanprapaph Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kumutnart Chanprapaph, Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama IV Road, Bangkok, 10400, Thailand, Tel +66 626393659, Email kumutnartp@hotmail.comObjective: To investigate the prevalence of low vitamin D levels in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) in Thailand and determine the influential factors associated with inadequate levels.Methods: The medical records of patients diagnosed with SLE and/or CLE and evaluated for serum 25-OH vitamin D were retrospectively reviewed from January 2014 to January 2021. Vitamin D deficiency (< 20 ng/mL) and insufficiency (21– 29 ng/mL) were indicated, and predictors of hypovitaminosis D were identified by multiple linear regression analysis.Results: In total, 414 patients with SLE and/or CLE were included in the study. Vitamin D deficiency was predominant in the CLE-only group (33.3%), followed by SLE without CLE (15.6%) and SLE with CLE (8%), p < 0.001. Likewise, vitamin D insufficiency was more prevalent in the CLE-only group (44.4%) compared to SLE with (35.8%) and without CLE (40%). Multivariate analysis showed that a higher SLEDAI-2K score and female sex had a negative association with vitamin D levels, while an intake of every 10,000 IU of vitamin D2 per week increased serum vitamin D levels by up to 2.37 ng/mL. Furthermore, forty-five percent of patients continued to have vitamin D depletion despite commencing the recommended doses of vitamin D replacement.Conclusion: Approximately half of Thai patients with SLE and 80% of CLE had vitamin D inadequacy. Vitamin D replacement is a good predictor of high serum vitamin D levels, while lower serum levels were associated with higher disease severity. Therefore, serum vitamin D monitoring and supplementation are suggested for all lupus erythematosus cases, especially those with CLE.Keywords: 25(OH) vitamin D, cutaneous lupus erythematosus, lupus, systemic lupus erythematosus, vitamin D status |
| first_indexed | 2024-12-10T18:43:06Z |
| format | Article |
| id | doaj.art-872e012f698a474aa26112cd550b0e10 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-10T18:43:06Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-872e012f698a474aa26112cd550b0e102022-12-22T01:37:36ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152022-08-01Volume 151663167177458High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in ThailandKanokrungsee SPatcharapojanart CSuchonwanit PChanprapaph KSilada Kanokrungsee, Chanikarn Patcharapojanart, Poonkiat Suchonwanit, Kumutnart Chanprapaph Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kumutnart Chanprapaph, Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama IV Road, Bangkok, 10400, Thailand, Tel +66 626393659, Email kumutnartp@hotmail.comObjective: To investigate the prevalence of low vitamin D levels in patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) in Thailand and determine the influential factors associated with inadequate levels.Methods: The medical records of patients diagnosed with SLE and/or CLE and evaluated for serum 25-OH vitamin D were retrospectively reviewed from January 2014 to January 2021. Vitamin D deficiency (< 20 ng/mL) and insufficiency (21– 29 ng/mL) were indicated, and predictors of hypovitaminosis D were identified by multiple linear regression analysis.Results: In total, 414 patients with SLE and/or CLE were included in the study. Vitamin D deficiency was predominant in the CLE-only group (33.3%), followed by SLE without CLE (15.6%) and SLE with CLE (8%), p < 0.001. Likewise, vitamin D insufficiency was more prevalent in the CLE-only group (44.4%) compared to SLE with (35.8%) and without CLE (40%). Multivariate analysis showed that a higher SLEDAI-2K score and female sex had a negative association with vitamin D levels, while an intake of every 10,000 IU of vitamin D2 per week increased serum vitamin D levels by up to 2.37 ng/mL. Furthermore, forty-five percent of patients continued to have vitamin D depletion despite commencing the recommended doses of vitamin D replacement.Conclusion: Approximately half of Thai patients with SLE and 80% of CLE had vitamin D inadequacy. Vitamin D replacement is a good predictor of high serum vitamin D levels, while lower serum levels were associated with higher disease severity. Therefore, serum vitamin D monitoring and supplementation are suggested for all lupus erythematosus cases, especially those with CLE.Keywords: 25(OH) vitamin D, cutaneous lupus erythematosus, lupus, systemic lupus erythematosus, vitamin D statushttps://www.dovepress.com/high-prevalence-of-hypovitaminosis-d-in-cutaneous-and-systemic-lupus-e-peer-reviewed-fulltext-article-CCID25(oh) vitamin dcutaneous lupus erythematosuslupussystemic lupus erythematosusvitamin d status |
| spellingShingle | Kanokrungsee S Patcharapojanart C Suchonwanit P Chanprapaph K High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand Clinical, Cosmetic and Investigational Dermatology 25(oh) vitamin d cutaneous lupus erythematosus lupus systemic lupus erythematosus vitamin d status |
| title | High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand |
| title_full | High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand |
| title_fullStr | High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand |
| title_full_unstemmed | High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand |
| title_short | High Prevalence of Hypovitaminosis D in Cutaneous and Systemic Lupus Erythematosus Patients and Its Associated Factors: A Cross-Sectional Study in Thailand |
| title_sort | high prevalence of hypovitaminosis d in cutaneous and systemic lupus erythematosus patients and its associated factors a cross sectional study in thailand |
| topic | 25(oh) vitamin d cutaneous lupus erythematosus lupus systemic lupus erythematosus vitamin d status |
| url | https://www.dovepress.com/high-prevalence-of-hypovitaminosis-d-in-cutaneous-and-systemic-lupus-e-peer-reviewed-fulltext-article-CCID |
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