Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes

Background: Atrial-ventricular differences in voltage-gated Na+ currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial fibrillation without risk of ventricular tachyarrhythmia. Eleclazine (GS-6615) is a putative antiarrhythmic drug with properties s...

Full description

Bibliographic Details
Main Authors: Rachel E. Caves, PhD, Alexander Carpenter, MRCP, Stéphanie C. Choisy, PhD, Ben Clennell, MSc, Hongwei Cheng, PhD, Cameron McNiff, BSc(Hons), Brendan Mann, BSc(Hons), James T. Milnes, PhD, Jules C. Hancox, DSc, Andrew F. James, DPhil
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Heart Rhythm O2
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666501820300453

Similar Items