Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes
Background: Atrial-ventricular differences in voltage-gated Na+ currents might be exploited for atrial-selective antiarrhythmic drug action for the suppression of atrial fibrillation without risk of ventricular tachyarrhythmia. Eleclazine (GS-6615) is a putative antiarrhythmic drug with properties s...
Main Authors: | Rachel E. Caves, PhD, Alexander Carpenter, MRCP, Stéphanie C. Choisy, PhD, Ben Clennell, MSc, Hongwei Cheng, PhD, Cameron McNiff, BSc(Hons), Brendan Mann, BSc(Hons), James T. Milnes, PhD, Jules C. Hancox, DSc, Andrew F. James, DPhil |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-08-01
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Series: | Heart Rhythm O2 |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666501820300453 |
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