The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review
In Southeast Asia, traditional medicine has a longestablished history and plays an important role in the health care system. Various traditional medicinal plants have been used to treat diseases since ancient times and much of this traditional knowledge remains preserved today. <i>Oroxylum ind...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5677 |
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| author | Nik Nur Hakimah Nik Salleh Farah Amna Othman Nur Alisa Kamarudin Suat Cheng Tan |
| author_facet | Nik Nur Hakimah Nik Salleh Farah Amna Othman Nur Alisa Kamarudin Suat Cheng Tan |
| author_sort | Nik Nur Hakimah Nik Salleh |
| collection | DOAJ |
| description | In Southeast Asia, traditional medicine has a longestablished history and plays an important role in the health care system. Various traditional medicinal plants have been used to treat diseases since ancient times and much of this traditional knowledge remains preserved today. <i>Oroxylum indicum</i> (beko plant) is one of the medicinal herb plants that is widely distributed throughout Asia. It is a versatile plant and almost every part of the plant is reported to possess a wide range of pharmacological activities. Many of the important bioactivities of this medicinal plant is related to the most abundant bioactive constituent found in this plant—the baicalein. Nonetheless, there is still no systematic review to report and vindicate the biological activities and therapeutic potential of baicalein extracted from <i>O. indicum</i> to treat human diseases. In this review, we aimed to systematically present in vivo and in vitro studies searched from PubMed, ScienceDirect, Scopus and Google Scholar database up to 31 March 2020 based on keywords “<i>Oroxylum indicum</i>” and “baicalein”. After an initial screening of titles and abstracts, followed by a full-text analysis and validation, 20 articles that fulfilled all the inclusion and exclusion criteria were included in this systematic review. The searched data comprehensively reported the biological activities and therapeutic potential of baicalein originating from the <i>O. indicum</i> plant for anti-cancer, antibacterial, anti-hyperglycemia, neurogenesis, cardioprotective, anti-adipogenesis, anti-inflammatory and wound healing effects. Nonetheless, we noticed that there was a scarcity of evidence on the efficacy of this natural active compound in human clinical studies. In conclusion, this systematic review article provides new insight into <i>O. indicum</i> and its active constituent baicalein as a prospective complementary therapy from the perspective of modern and scientific aspect. We indicate the potential of this natural product to be developed into more conscientious and judicious evidencebased medicine in the future. However, we also recommend more clinical research to confirm the efficacy and safety of baicalein as therapeutic medicine for patients. |
| first_indexed | 2024-03-10T14:23:25Z |
| format | Article |
| id | doaj.art-8730879f1cdc494587f8119919c296dd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:23:25Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8730879f1cdc494587f8119919c296dd2023-11-20T23:11:04ZengMDPI AGMolecules1420-30492020-12-012523567710.3390/molecules25235677The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic ReviewNik Nur Hakimah Nik Salleh0Farah Amna Othman1Nur Alisa Kamarudin2Suat Cheng Tan3School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaIn Southeast Asia, traditional medicine has a longestablished history and plays an important role in the health care system. Various traditional medicinal plants have been used to treat diseases since ancient times and much of this traditional knowledge remains preserved today. <i>Oroxylum indicum</i> (beko plant) is one of the medicinal herb plants that is widely distributed throughout Asia. It is a versatile plant and almost every part of the plant is reported to possess a wide range of pharmacological activities. Many of the important bioactivities of this medicinal plant is related to the most abundant bioactive constituent found in this plant—the baicalein. Nonetheless, there is still no systematic review to report and vindicate the biological activities and therapeutic potential of baicalein extracted from <i>O. indicum</i> to treat human diseases. In this review, we aimed to systematically present in vivo and in vitro studies searched from PubMed, ScienceDirect, Scopus and Google Scholar database up to 31 March 2020 based on keywords “<i>Oroxylum indicum</i>” and “baicalein”. After an initial screening of titles and abstracts, followed by a full-text analysis and validation, 20 articles that fulfilled all the inclusion and exclusion criteria were included in this systematic review. The searched data comprehensively reported the biological activities and therapeutic potential of baicalein originating from the <i>O. indicum</i> plant for anti-cancer, antibacterial, anti-hyperglycemia, neurogenesis, cardioprotective, anti-adipogenesis, anti-inflammatory and wound healing effects. Nonetheless, we noticed that there was a scarcity of evidence on the efficacy of this natural active compound in human clinical studies. In conclusion, this systematic review article provides new insight into <i>O. indicum</i> and its active constituent baicalein as a prospective complementary therapy from the perspective of modern and scientific aspect. We indicate the potential of this natural product to be developed into more conscientious and judicious evidencebased medicine in the future. However, we also recommend more clinical research to confirm the efficacy and safety of baicalein as therapeutic medicine for patients.https://www.mdpi.com/1420-3049/25/23/5677<i>Oroxylum indicum</i>baicaleinmedicinal plantbiological activitiestherapeutic potential |
| spellingShingle | Nik Nur Hakimah Nik Salleh Farah Amna Othman Nur Alisa Kamarudin Suat Cheng Tan The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review Molecules <i>Oroxylum indicum</i> baicalein medicinal plant biological activities therapeutic potential |
| title | The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review |
| title_full | The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review |
| title_fullStr | The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review |
| title_full_unstemmed | The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review |
| title_short | The Biological Activities and Therapeutic Potentials of Baicalein Extracted from <i>Oroxylum indicum</i>: A Systematic Review |
| title_sort | biological activities and therapeutic potentials of baicalein extracted from i oroxylum indicum i a systematic review |
| topic | <i>Oroxylum indicum</i> baicalein medicinal plant biological activities therapeutic potential |
| url | https://www.mdpi.com/1420-3049/25/23/5677 |
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