Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 million infections and 6 million deaths worldwide. Early detection and quarantine are essential to arrest the spread of the highly...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-11-01
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| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304222003178 |
| _version_ | 1797762798388772864 |
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| author | Qianqian Zhou Yanhua Chen Ruolei Wang Fengjing Jia Feng He Fuwen Yuan |
| author_facet | Qianqian Zhou Yanhua Chen Ruolei Wang Fengjing Jia Feng He Fuwen Yuan |
| author_sort | Qianqian Zhou |
| collection | DOAJ |
| description | The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 million infections and 6 million deaths worldwide. Early detection and quarantine are essential to arrest the spread of the highly contagious COVID-19. High-risk groups, such as older adults and individuals with comorbidities, can present severe symptoms, including pyrexia, pertussis, and acute respiratory distress syndrome, on SARS-CoV-2 infection that can prove fatal, demonstrating a clear need for high-throughput and sensitive platforms to detect and eliminate SARS-CoV-2. CRISPR-Cas13, an emerging CRISPR system targeting RNA with high specificity and efficiency, has recently drawn much attention for COVID-19 diagnosis and treatment. Here, we summarized the current research progress on CRISPR-Cas13 in COVID-19 diagnosis and treatment and highlight the challenges and future research directions of CRISPR-Cas13 for effectively counteracting COVID-19. |
| first_indexed | 2024-03-12T19:32:38Z |
| format | Article |
| id | doaj.art-873243dcef404f5cb4876c1341e9c609 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T19:32:38Z |
| publishDate | 2023-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-873243dcef404f5cb4876c1341e9c6092023-08-02T04:24:29ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-11-0110624142424Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatmentQianqian Zhou0Yanhua Chen1Ruolei Wang2Fengjing Jia3Feng He4Fuwen Yuan5Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCorresponding author.; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaThe ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in over 570 million infections and 6 million deaths worldwide. Early detection and quarantine are essential to arrest the spread of the highly contagious COVID-19. High-risk groups, such as older adults and individuals with comorbidities, can present severe symptoms, including pyrexia, pertussis, and acute respiratory distress syndrome, on SARS-CoV-2 infection that can prove fatal, demonstrating a clear need for high-throughput and sensitive platforms to detect and eliminate SARS-CoV-2. CRISPR-Cas13, an emerging CRISPR system targeting RNA with high specificity and efficiency, has recently drawn much attention for COVID-19 diagnosis and treatment. Here, we summarized the current research progress on CRISPR-Cas13 in COVID-19 diagnosis and treatment and highlight the challenges and future research directions of CRISPR-Cas13 for effectively counteracting COVID-19.http://www.sciencedirect.com/science/article/pii/S2352304222003178COVID-19CRISPR-Cas13DiagnosisSARS-CoV-2Treatment |
| spellingShingle | Qianqian Zhou Yanhua Chen Ruolei Wang Fengjing Jia Feng He Fuwen Yuan Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment Genes and Diseases COVID-19 CRISPR-Cas13 Diagnosis SARS-CoV-2 Treatment |
| title | Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment |
| title_full | Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment |
| title_fullStr | Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment |
| title_full_unstemmed | Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment |
| title_short | Advances of CRISPR-Cas13 system in COVID-19 diagnosis and treatment |
| title_sort | advances of crispr cas13 system in covid 19 diagnosis and treatment |
| topic | COVID-19 CRISPR-Cas13 Diagnosis SARS-CoV-2 Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2352304222003178 |
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