Lung function in adults born preterm.
Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function and whether any associations are explained by maternal, early life/neonatal,...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6195283?pdf=render |
| _version_ | 1819102031910010880 |
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| author | Pieta Näsänen-Gilmore Marika Sipola-Leppänen Marjaana Tikanmäki Hanna-Maria Matinolli Johan G Eriksson Marjo-Riitta Järvelin Marja Vääräsmäki Petteri Hovi Eero Kajantie |
| author_facet | Pieta Näsänen-Gilmore Marika Sipola-Leppänen Marjaana Tikanmäki Hanna-Maria Matinolli Johan G Eriksson Marjo-Riitta Järvelin Marja Vääräsmäki Petteri Hovi Eero Kajantie |
| author_sort | Pieta Näsänen-Gilmore |
| collection | DOAJ |
| description | Very preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function and whether any associations are explained by maternal, early life/neonatal, or current life factors. Participants of the ESTER Preterm Birth Study, born between 1985 and 1989 (during the pre-surfactant era), at the age of 23 years participated in a clinical study in which they performed spirometry and provided detailed medical history. Of the participants, 139 were born early preterm (GA<34 weeks), 239 late preterm (GA: 34-<37 weeks), and 341 full-term (GA≥37 weeks). Preterm birth was associated with poorer lung function. Mean differences between individuals born early preterm versus full-term were -0.23 standard deviation (SD) (95% confidence interval (CI): -0.40, -0.05)) for forced vital capacity z-score (zFVC), -0.44 SD (95% CI -0.64, -0.25) for forced expiratory volume z-score (zFEV1), and -0.29 SD (95% CI -0.47, -0.10) for zFEV1/FVC. For late preterm, mean differences with full-term controls were -0.02 SD (95% CI -0.17, 0.13), -0.12 SD (95% CI -0.29, 0.04) and -0.13 SD (95% CI -0.29, 0.02) for zFVC, zFEV1, and zFEV1/FVC, respectively. Examination of finer GA subgroups suggested an inverse non-linear association between lung function and GA, with the greatest impact on zFEV1 for those born extremely preterm. The subgroup means were GA<28 weeks: -0.98 SD; 28-<32 weeks: -0.29 SD; 32-<34 weeks: -0.44 SD; 34-<36 weeks: -0.10 SD; 36-<37weeks: -0.11 SD; term-born controls (≥37weeks): 0.02 SD. Corresponding means for zFEV1/FVC were -1.79, -0.44, -0.47, -0.48, -0.29, and -0.02. Adjustment for maternal pregnancy conditions and socioeconomic and lifestyle factors had no major impact on the relationship. Preterm birth is associated with airflow limitation in adult life. The association appears to be attributable predominantly to those born most immature, with only a modest decrease among those born preterm at later gestational ages. |
| first_indexed | 2024-12-22T01:28:06Z |
| format | Article |
| id | doaj.art-8734fb4b01564084b7f2ec0a667f0799 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:28:06Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8734fb4b01564084b7f2ec0a667f07992022-12-21T18:43:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e020597910.1371/journal.pone.0205979Lung function in adults born preterm.Pieta Näsänen-GilmoreMarika Sipola-LeppänenMarjaana TikanmäkiHanna-Maria MatinolliJohan G ErikssonMarjo-Riitta JärvelinMarja VääräsmäkiPetteri HoviEero KajantieVery preterm birth, before the gestational age (GA) of 32 weeks, increases the risk of obstructed airflow in adulthood. We examined whether all preterm births (GA<37 weeks) are associated with poorer adult lung function and whether any associations are explained by maternal, early life/neonatal, or current life factors. Participants of the ESTER Preterm Birth Study, born between 1985 and 1989 (during the pre-surfactant era), at the age of 23 years participated in a clinical study in which they performed spirometry and provided detailed medical history. Of the participants, 139 were born early preterm (GA<34 weeks), 239 late preterm (GA: 34-<37 weeks), and 341 full-term (GA≥37 weeks). Preterm birth was associated with poorer lung function. Mean differences between individuals born early preterm versus full-term were -0.23 standard deviation (SD) (95% confidence interval (CI): -0.40, -0.05)) for forced vital capacity z-score (zFVC), -0.44 SD (95% CI -0.64, -0.25) for forced expiratory volume z-score (zFEV1), and -0.29 SD (95% CI -0.47, -0.10) for zFEV1/FVC. For late preterm, mean differences with full-term controls were -0.02 SD (95% CI -0.17, 0.13), -0.12 SD (95% CI -0.29, 0.04) and -0.13 SD (95% CI -0.29, 0.02) for zFVC, zFEV1, and zFEV1/FVC, respectively. Examination of finer GA subgroups suggested an inverse non-linear association between lung function and GA, with the greatest impact on zFEV1 for those born extremely preterm. The subgroup means were GA<28 weeks: -0.98 SD; 28-<32 weeks: -0.29 SD; 32-<34 weeks: -0.44 SD; 34-<36 weeks: -0.10 SD; 36-<37weeks: -0.11 SD; term-born controls (≥37weeks): 0.02 SD. Corresponding means for zFEV1/FVC were -1.79, -0.44, -0.47, -0.48, -0.29, and -0.02. Adjustment for maternal pregnancy conditions and socioeconomic and lifestyle factors had no major impact on the relationship. Preterm birth is associated with airflow limitation in adult life. The association appears to be attributable predominantly to those born most immature, with only a modest decrease among those born preterm at later gestational ages.http://europepmc.org/articles/PMC6195283?pdf=render |
| spellingShingle | Pieta Näsänen-Gilmore Marika Sipola-Leppänen Marjaana Tikanmäki Hanna-Maria Matinolli Johan G Eriksson Marjo-Riitta Järvelin Marja Vääräsmäki Petteri Hovi Eero Kajantie Lung function in adults born preterm. PLoS ONE |
| title | Lung function in adults born preterm. |
| title_full | Lung function in adults born preterm. |
| title_fullStr | Lung function in adults born preterm. |
| title_full_unstemmed | Lung function in adults born preterm. |
| title_short | Lung function in adults born preterm. |
| title_sort | lung function in adults born preterm |
| url | http://europepmc.org/articles/PMC6195283?pdf=render |
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