Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis
Abstract Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness. This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS-CoV). SARS was first detected in Asia in late February 2003. The genome of this virus is very similar to the SARS...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01410-3 |
| _version_ | 1798032971021680640 |
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| author | Habib MotieGhader Esmaeil Safavi Ali Rezapour Fatemeh Firouzi Amoodizaj Roya asl Iranifam |
| author_facet | Habib MotieGhader Esmaeil Safavi Ali Rezapour Fatemeh Firouzi Amoodizaj Roya asl Iranifam |
| author_sort | Habib MotieGhader |
| collection | DOAJ |
| description | Abstract Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness. This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS-CoV). SARS was first detected in Asia in late February 2003. The genome of this virus is very similar to the SARS-CoV-2. Therefore, the study of SARS-CoV disease and the identification of effective drugs to treat this disease can be new clues for the treatment of SARS-Cov-2. This study aimed to discover novel potential drugs for SARS-CoV disease in order to treating SARS-Cov-2 disease based on a novel systems biology approach. To this end, gene co-expression network analysis was applied. First, the gene co-expression network was reconstructed for 1441 genes, and then two gene modules were discovered as significant modules. Next, a list of miRNAs and transcription factors that target gene co-expression modules' genes were gathered from the valid databases, and two sub-networks formed of transcription factors and miRNAs were established. Afterward, the list of the drugs targeting obtained sub-networks' genes was retrieved from the DGIDb database, and two drug-gene and drug-TF interaction networks were reconstructed. Finally, after conducting different network analyses, we proposed five drugs, including FLUOROURACIL, CISPLATIN, SIROLIMUS, CYCLOPHOSPHAMIDE, and METHYLDOPA, as candidate drugs for SARS-CoV-2 coronavirus treatment. Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus. |
| first_indexed | 2024-04-11T20:22:54Z |
| format | Article |
| id | doaj.art-8735a5f95a134ce383de74f1344a20bc |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T20:22:54Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8735a5f95a134ce383de74f1344a20bc2022-12-22T04:04:46ZengNature PortfolioScientific Reports2045-23222021-11-0111111510.1038/s41598-021-01410-3Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysisHabib MotieGhader0Esmaeil Safavi1Ali Rezapour2Fatemeh Firouzi Amoodizaj3Roya asl Iranifam4Department of Basic Sciences, Biotechnology Research Center, Tabriz Branch, Islamic Azad UniversityDepartment of Basic Sciences, Biotechnology Research Center, Tabriz Branch, Islamic Azad UniversityDepartment of Animal Science, Faculty of Agriculture, Tabriz Branch, Islamic Azad UniversityDepartment of Basic Sciences, Biotechnology Research Center, Tabriz Branch, Islamic Azad UniversityDepartment of Basic Sciences, Biotechnology Research Center, Tabriz Branch, Islamic Azad UniversityAbstract Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness. This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS-CoV). SARS was first detected in Asia in late February 2003. The genome of this virus is very similar to the SARS-CoV-2. Therefore, the study of SARS-CoV disease and the identification of effective drugs to treat this disease can be new clues for the treatment of SARS-Cov-2. This study aimed to discover novel potential drugs for SARS-CoV disease in order to treating SARS-Cov-2 disease based on a novel systems biology approach. To this end, gene co-expression network analysis was applied. First, the gene co-expression network was reconstructed for 1441 genes, and then two gene modules were discovered as significant modules. Next, a list of miRNAs and transcription factors that target gene co-expression modules' genes were gathered from the valid databases, and two sub-networks formed of transcription factors and miRNAs were established. Afterward, the list of the drugs targeting obtained sub-networks' genes was retrieved from the DGIDb database, and two drug-gene and drug-TF interaction networks were reconstructed. Finally, after conducting different network analyses, we proposed five drugs, including FLUOROURACIL, CISPLATIN, SIROLIMUS, CYCLOPHOSPHAMIDE, and METHYLDOPA, as candidate drugs for SARS-CoV-2 coronavirus treatment. Moreover, ten miRNAs including miR-193b, miR-192, miR-215, miR-34a, miR-16, miR-16, miR-92a, miR-30a, miR-7, and miR-26b were found to be significant miRNAs in treating SARS-CoV-2 coronavirus.https://doi.org/10.1038/s41598-021-01410-3 |
| spellingShingle | Habib MotieGhader Esmaeil Safavi Ali Rezapour Fatemeh Firouzi Amoodizaj Roya asl Iranifam Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis Scientific Reports |
| title | Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis |
| title_full | Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis |
| title_fullStr | Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis |
| title_full_unstemmed | Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis |
| title_short | Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis |
| title_sort | drug repurposing for coronavirus sars cov 2 based on gene co expression network analysis |
| url | https://doi.org/10.1038/s41598-021-01410-3 |
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