Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway
The ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression of HIF-1α and ERK accompanies CCl4-induced liver fibrosis in rats. Curcumin is verified to have antifibrotic effects in several kinds of liver fibrosis models....
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/11/18767 |
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| author | Yanling Zhao Xiao Ma Jiabo Wang Xuan He Yan Hu Ping Zhang Ruilin Wang Ruisheng Li Man Gong Shengqiang Luo Xiaohe Xiao |
| author_facet | Yanling Zhao Xiao Ma Jiabo Wang Xuan He Yan Hu Ping Zhang Ruilin Wang Ruisheng Li Man Gong Shengqiang Luo Xiaohe Xiao |
| author_sort | Yanling Zhao |
| collection | DOAJ |
| description | The ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression of HIF-1α and ERK accompanies CCl4-induced liver fibrosis in rats. Curcumin is verified to have antifibrotic effects in several kinds of liver fibrosis models. There is no specific evidence illustrating a connection between curcumin and the HIF-1α/ERK pathway in rat liver fibrosis induced by CCl4. In this study, liver fibrosis was induced by CCl4 in treated rats. The data demonstrated that curcumin was able to attenuate liver fibrosis and inhibit the proliferation of HSC. Moreover, curcumin could remarkably elevate the hepatic function by decreasing serum levels of ALT, AST and ALP, and increasing levels of ALB, TP and α-SMA, Col III mRNA expression. Meanwhile, ECM status could also be reflected by curcumin treatment. The alleviation with curcumin treatment was associated with inhibition of HIF-1α and phosphor-ERK. This study indicates that curcumin alleviates fibrosis by reducing the expression of HIF-1α partly through the ERK pathway. |
| first_indexed | 2024-12-21T18:35:53Z |
| format | Article |
| id | doaj.art-8736482c582647c5b4ce28351faa29d1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T18:35:53Z |
| publishDate | 2014-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8736482c582647c5b4ce28351faa29d12022-12-21T18:54:09ZengMDPI AGMolecules1420-30492014-11-011911187671878010.3390/molecules191118767molecules191118767Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent PathwayYanling Zhao0Xiao Ma1Jiabo Wang2Xuan He3Yan Hu4Ping Zhang5Ruilin Wang6Ruisheng Li7Man Gong8Shengqiang Luo9Xiaohe Xiao10China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, ChinaChina Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, ChinaChina Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, ChinaResearch and Technology Service Center, 302 Military Hospital of China, Beijing 100039, ChinaDepartment of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, ChinaDepartment of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, ChinaResearch and Technology Service Center, 302 Military Hospital of China, Beijing 100039, ChinaDepartment of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, ChinaDepartment of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, ChinaChina Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, ChinaThe ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression of HIF-1α and ERK accompanies CCl4-induced liver fibrosis in rats. Curcumin is verified to have antifibrotic effects in several kinds of liver fibrosis models. There is no specific evidence illustrating a connection between curcumin and the HIF-1α/ERK pathway in rat liver fibrosis induced by CCl4. In this study, liver fibrosis was induced by CCl4 in treated rats. The data demonstrated that curcumin was able to attenuate liver fibrosis and inhibit the proliferation of HSC. Moreover, curcumin could remarkably elevate the hepatic function by decreasing serum levels of ALT, AST and ALP, and increasing levels of ALB, TP and α-SMA, Col III mRNA expression. Meanwhile, ECM status could also be reflected by curcumin treatment. The alleviation with curcumin treatment was associated with inhibition of HIF-1α and phosphor-ERK. This study indicates that curcumin alleviates fibrosis by reducing the expression of HIF-1α partly through the ERK pathway.http://www.mdpi.com/1420-3049/19/11/18767curcumincarbon tetrachlorideliver fibrosishypoxia inducible factor |
| spellingShingle | Yanling Zhao Xiao Ma Jiabo Wang Xuan He Yan Hu Ping Zhang Ruilin Wang Ruisheng Li Man Gong Shengqiang Luo Xiaohe Xiao Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway Molecules curcumin carbon tetrachloride liver fibrosis hypoxia inducible factor |
| title | Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway |
| title_full | Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway |
| title_fullStr | Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway |
| title_full_unstemmed | Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway |
| title_short | Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway |
| title_sort | curcumin protects against ccl4 induced liver fibrosis in rats by inhibiting hif 1α through an erk dependent pathway |
| topic | curcumin carbon tetrachloride liver fibrosis hypoxia inducible factor |
| url | http://www.mdpi.com/1420-3049/19/11/18767 |
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