Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway

Curcumin Protects against CCl4-Induced Liver Fibrosis in Rats by Inhibiting HIF-1α Through an ERK-Dependent Pathway

The ERK/HIF-1α signaling pathway is believed to play an important role in the genesis of progressive fibrosis. An increasing expression of HIF-1α and ERK accompanies CCl4-induced liver fibrosis in rats. Curcumin is verified to have antifibrotic effects in several kinds of liver fibrosis models....

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Bibliographic Details
Main Authors: Yanling Zhao, Xiao Ma, Jiabo Wang, Xuan He, Yan Hu, Ping Zhang, Ruilin Wang, Ruisheng Li, Man Gong, Shengqiang Luo, Xiaohe Xiao
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
curcumin
carbon tetrachloride
liver fibrosis
hypoxia inducible factor
Online Access:http://www.mdpi.com/1420-3049/19/11/18767

Internet

http://www.mdpi.com/1420-3049/19/11/18767

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