Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues
Antimicrobial peptides (AMPs) are widely distributed throughout the biosphere and represent a class of conserved peptide molecules with intrinsic antimicrobial properties. Their broad-spectrum antimicrobial activity and low risk to induce resistance have led to increased interest in AMPs as potentia...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1359261/full |
| _version_ | 1797305236661993472 |
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| author | Clara Appiah Shitian Chen Afia Ibnat Pori Vladimir Retyunskiy Chimeng Tzeng Ye Zhao |
| author_facet | Clara Appiah Shitian Chen Afia Ibnat Pori Vladimir Retyunskiy Chimeng Tzeng Ye Zhao |
| author_sort | Clara Appiah |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are widely distributed throughout the biosphere and represent a class of conserved peptide molecules with intrinsic antimicrobial properties. Their broad-spectrum antimicrobial activity and low risk to induce resistance have led to increased interest in AMPs as potential alternatives to traditional antibiotics. Among the AMPs, alloferon has been addressed due to its immunomodulatory properties that augment both innate and adaptive immune responses against various pathogens. Alloferon and its analogues have demonstrated pharmaceutical potential through their ability to enhance Natural Killer (NK) cell cytotoxicity and stimulate interferon (IFN) synthesis in both mouse and human models. Additionally, they have shown promise in augmenting antiviral and antitumor activities in mice. In this article, we provide a comprehensive review of the biological effects of alloferon and its analogues, incorporating our own research findings as well. These insights may contribute to a deeper understanding of the therapeutic potential of these novel AMPs. |
| first_indexed | 2024-03-08T00:22:05Z |
| format | Article |
| id | doaj.art-87366a206c704fab9dbb7a12dc668f1f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-08T00:22:05Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-87366a206c704fab9dbb7a12dc668f1f2024-02-16T04:58:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13592611359261Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analoguesClara Appiah0Shitian Chen1Afia Ibnat Pori2Vladimir Retyunskiy3Chimeng Tzeng4Ye Zhao5School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, ChinaSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, ChinaSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, ChinaSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, ChinaSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, ChinaSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, ChinaAntimicrobial peptides (AMPs) are widely distributed throughout the biosphere and represent a class of conserved peptide molecules with intrinsic antimicrobial properties. Their broad-spectrum antimicrobial activity and low risk to induce resistance have led to increased interest in AMPs as potential alternatives to traditional antibiotics. Among the AMPs, alloferon has been addressed due to its immunomodulatory properties that augment both innate and adaptive immune responses against various pathogens. Alloferon and its analogues have demonstrated pharmaceutical potential through their ability to enhance Natural Killer (NK) cell cytotoxicity and stimulate interferon (IFN) synthesis in both mouse and human models. Additionally, they have shown promise in augmenting antiviral and antitumor activities in mice. In this article, we provide a comprehensive review of the biological effects of alloferon and its analogues, incorporating our own research findings as well. These insights may contribute to a deeper understanding of the therapeutic potential of these novel AMPs.https://www.frontiersin.org/articles/10.3389/fphar.2024.1359261/fullalloferonantimicrobial peptidesNK cellIFNantivirus |
| spellingShingle | Clara Appiah Shitian Chen Afia Ibnat Pori Vladimir Retyunskiy Chimeng Tzeng Ye Zhao Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues Frontiers in Pharmacology alloferon antimicrobial peptides NK cell IFN antivirus |
| title | Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues |
| title_full | Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues |
| title_fullStr | Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues |
| title_full_unstemmed | Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues |
| title_short | Study of alloferon, a novel immunomodulatory antimicrobial peptide (AMP), and its analogues |
| title_sort | study of alloferon a novel immunomodulatory antimicrobial peptide amp and its analogues |
| topic | alloferon antimicrobial peptides NK cell IFN antivirus |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1359261/full |
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