Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study”
Background. Despite ongoing treatment advancements in chronic heart failure (HF), mortality and readmission rates remain high for patients hospitalized for decompensated acute HF. These patients represent a distinct HF group, which requires emergent echocardiographic evaluation in an attempt to prov...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/6/1191 |
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| author | Vasileios Anastasiou Stylianos Daios Dimitrios V. Moysidis Maria-Anna Bazmpani Thomas Zegkos Theodoros Karamitsos Kali Makedou Christos Savopoulos Georgios Efthimiadis Antonios Ziakas Vasileios Kamperidis |
| author_facet | Vasileios Anastasiou Stylianos Daios Dimitrios V. Moysidis Maria-Anna Bazmpani Thomas Zegkos Theodoros Karamitsos Kali Makedou Christos Savopoulos Georgios Efthimiadis Antonios Ziakas Vasileios Kamperidis |
| author_sort | Vasileios Anastasiou |
| collection | DOAJ |
| description | Background. Despite ongoing treatment advancements in chronic heart failure (HF), mortality and readmission rates remain high for patients hospitalized for decompensated acute HF. These patients represent a distinct HF group, which requires emergent echocardiographic evaluation in an attempt to provide optimal and individualized acute care. The role of serial advanced echocardiographic assessment in acute HF for risk stratification and treatment guidance has not been thoroughly explored. Methods. The “Beyond Myo-HF Study” is a prospective, non-interventional cohort trial designed to enroll acutely admitted patients with symptoms and/or signs of HF. The aim of this study is to investigate whether intrahospital changes of conventional and novel echocardiographic indices of myocardial function and congestion-related markers can predict early mortality, late mortality, and HF rehospitalization. As per the protocol, all patients undergo a pair of state-of-the-art echocardiographic assessments, with a rigorous protocol including speckle tracking analysis of all cardiac chambers and myocardial work analysis for the left and right ventricle, upon admission and pre-discharge. Their laboratory profile is captured at those two time-points, and their therapeutic management is recorded. Patients will be followed-up for a median period of 12 months after enrollment. Conclusions. The “Beyond Myo-HF” study is an ongoing, prospective trial aspiring to provide deep insight into the pathophysiology of acute HF, to enlighten the reverse cardiac functional and anatomical remodeling during hospitalization, and to recognize echocardiographic patterns capable of predicting adverse outcomes during and post decompensation of acute HF. |
| first_indexed | 2024-03-11T06:40:56Z |
| format | Article |
| id | doaj.art-873832d6a02a4d78bd12f010cb253bc4 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T06:40:56Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-873832d6a02a4d78bd12f010cb253bc42023-11-17T10:35:34ZengMDPI AGDiagnostics2075-44182023-03-01136119110.3390/diagnostics13061191Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study”Vasileios Anastasiou0Stylianos Daios1Dimitrios V. Moysidis2Maria-Anna Bazmpani3Thomas Zegkos4Theodoros Karamitsos5Kali Makedou6Christos Savopoulos7Georgios Efthimiadis8Antonios Ziakas9Vasileios Kamperidis10First Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceLaboratory of Biochemistry, AHEPA Hospital, Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Propedeutic Department of Internal Medicine, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceFirst Department of Cardiology, AHEPA Hospital, School of Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceBackground. Despite ongoing treatment advancements in chronic heart failure (HF), mortality and readmission rates remain high for patients hospitalized for decompensated acute HF. These patients represent a distinct HF group, which requires emergent echocardiographic evaluation in an attempt to provide optimal and individualized acute care. The role of serial advanced echocardiographic assessment in acute HF for risk stratification and treatment guidance has not been thoroughly explored. Methods. The “Beyond Myo-HF Study” is a prospective, non-interventional cohort trial designed to enroll acutely admitted patients with symptoms and/or signs of HF. The aim of this study is to investigate whether intrahospital changes of conventional and novel echocardiographic indices of myocardial function and congestion-related markers can predict early mortality, late mortality, and HF rehospitalization. As per the protocol, all patients undergo a pair of state-of-the-art echocardiographic assessments, with a rigorous protocol including speckle tracking analysis of all cardiac chambers and myocardial work analysis for the left and right ventricle, upon admission and pre-discharge. Their laboratory profile is captured at those two time-points, and their therapeutic management is recorded. Patients will be followed-up for a median period of 12 months after enrollment. Conclusions. The “Beyond Myo-HF” study is an ongoing, prospective trial aspiring to provide deep insight into the pathophysiology of acute HF, to enlighten the reverse cardiac functional and anatomical remodeling during hospitalization, and to recognize echocardiographic patterns capable of predicting adverse outcomes during and post decompensation of acute HF.https://www.mdpi.com/2075-4418/13/6/1191acute heart failureechocardiographymyocardial worknovel imaging biomarkersresponse to treatmentprognosis |
| spellingShingle | Vasileios Anastasiou Stylianos Daios Dimitrios V. Moysidis Maria-Anna Bazmpani Thomas Zegkos Theodoros Karamitsos Kali Makedou Christos Savopoulos Georgios Efthimiadis Antonios Ziakas Vasileios Kamperidis Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study” Diagnostics acute heart failure echocardiography myocardial work novel imaging biomarkers response to treatment prognosis |
| title | Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study” |
| title_full | Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study” |
| title_fullStr | Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study” |
| title_full_unstemmed | Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study” |
| title_short | Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study” |
| title_sort | clinical value of novel echocardiographic biomarkers assessing myocardial work in acute heart failure rationale and design of the beyond myo hf study |
| topic | acute heart failure echocardiography myocardial work novel imaging biomarkers response to treatment prognosis |
| url | https://www.mdpi.com/2075-4418/13/6/1191 |
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