Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性)
合成了6种对称胺的二碘合铂(II)配合物cis-[Pt(CH3NH2)2I2](1),cis-[Pt(C2H5NH2)2I2](2)和cis-[Pt(—NH2)2I2](3)以及不对称胺的二碘合铂(II)配合物cis-[Pt (CH3NH2) (NH3)I2](4),cis-[Pt (C2H5NH2) (NH3)I2](5)和(cis-[Pt(—NH2)(NH3)I2](6).用元素分析和红外光谱对其进行了表征.体外抗肿瘤活性表明,不对称胺的二碘合铂(II)配合物的抗肿瘤活性明显好于其相应的对称胺的二碘合铂(II)配合物,载体基团环己胺可能是非常重要的药效基团....
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Zhejiang University Press
2005-05-01
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Series: | Zhejiang Daxue xuebao. Lixue ban |
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Online Access: | https://doi.org/zjup/1008-9497.2005.32.3.292-294 |
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author | ZHANGJin-chao(张金超) GONGYu-qiu(龚钰秋) ZHENGXiao-ming(郑小明) GUIJing-rong(崔景荣) YANGMeng-su(杨梦苏) |
author_facet | ZHANGJin-chao(张金超) GONGYu-qiu(龚钰秋) ZHENGXiao-ming(郑小明) GUIJing-rong(崔景荣) YANGMeng-su(杨梦苏) |
author_sort | ZHANGJin-chao(张金超) |
collection | DOAJ |
description | 合成了6种对称胺的二碘合铂(II)配合物cis-[Pt(CH3NH2)2I2](1),cis-[Pt(C2H5NH2)2I2](2)和cis-[Pt(—NH2)2I2](3)以及不对称胺的二碘合铂(II)配合物cis-[Pt (CH3NH2) (NH3)I2](4),cis-[Pt (C2H5NH2) (NH3)I2](5)和(cis-[Pt(—NH2)(NH3)I2](6).用元素分析和红外光谱对其进行了表征.体外抗肿瘤活性表明,不对称胺的二碘合铂(II)配合物的抗肿瘤活性明显好于其相应的对称胺的二碘合铂(II)配合物,载体基团环己胺可能是非常重要的药效基团. |
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language | zho |
last_indexed | 2024-04-24T17:02:55Z |
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spelling | doaj.art-873a514c25ef48f395de2a40cc3112d92024-03-29T01:58:22ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972005-05-01323292294zjup/1008-9497.2005.32.3.292-294Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性)ZHANGJin-chao(张金超)0GONGYu-qiu(龚钰秋)1ZHENGXiao-ming(郑小明)2GUIJing-rong(崔景荣)3YANGMeng-su(杨梦苏)4 1.Department of Chemistry, Zhejiang University, Hangzhou 310028, China( 1.浙江大学化学系,浙江 杭州 310028) 1.Department of Chemistry, Zhejiang University, Hangzhou 310028, China( 1.浙江大学化学系,浙江 杭州 310028) 1.Department of Chemistry, Zhejiang University, Hangzhou 310028, China( 1.浙江大学化学系,浙江 杭州 310028) 3.Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China( 3.北京大学天然药物及仿生药物国家重点实验室,北京 100083) 4.Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, China( 4.香港城市大学生物及化学系,香港)合成了6种对称胺的二碘合铂(II)配合物cis-[Pt(CH3NH2)2I2](1),cis-[Pt(C2H5NH2)2I2](2)和cis-[Pt(—NH2)2I2](3)以及不对称胺的二碘合铂(II)配合物cis-[Pt (CH3NH2) (NH3)I2](4),cis-[Pt (C2H5NH2) (NH3)I2](5)和(cis-[Pt(—NH2)(NH3)I2](6).用元素分析和红外光谱对其进行了表征.体外抗肿瘤活性表明,不对称胺的二碘合铂(II)配合物的抗肿瘤活性明显好于其相应的对称胺的二碘合铂(II)配合物,载体基团环己胺可能是非常重要的药效基团.https://doi.org/zjup/1008-9497.2005.32.3.292-294铂(ii)类配合物合成抗肿瘤活性 |
spellingShingle | ZHANGJin-chao(张金超) GONGYu-qiu(龚钰秋) ZHENGXiao-ming(郑小明) GUIJing-rong(崔景荣) YANGMeng-su(杨梦苏) Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性) Zhejiang Daxue xuebao. Lixue ban 铂(ii)类配合物 合成 抗肿瘤活性 |
title | Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性) |
title_full | Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性) |
title_fullStr | Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性) |
title_full_unstemmed | Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性) |
title_short | Synthesis and antitumor activity of diiodo-platinum (II) complexes with symmetry and asymmetry amines(对称胺和不对称胺的二碘合铂(II)混配配合物的合成及其抗肿瘤活性) |
title_sort | synthesis and antitumor activity of diiodo platinum ii complexes with symmetry and asymmetry amines 对称胺和不对称胺的二碘合铂 ii 混配配合物的合成及其抗肿瘤活性 |
topic | 铂(ii)类配合物 合成 抗肿瘤活性 |
url | https://doi.org/zjup/1008-9497.2005.32.3.292-294 |
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