Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis
BackgroundThis meta-analysis was performed to assess the prevalence and circulating strains of rotavirus (RV) among Chinese children under 5 years of age after the implantation of the RV vaccine.Material and methodsStudies published between 2019 and 2023, focused on RV-based diarrhea among children...
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| Format: | Article |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364429/full |
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| author | Yue Li Sijie Wang Sijie Wang Fan Liang Sashuang Teng Fei Wang |
| author_facet | Yue Li Sijie Wang Sijie Wang Fan Liang Sashuang Teng Fei Wang |
| author_sort | Yue Li |
| collection | DOAJ |
| description | BackgroundThis meta-analysis was performed to assess the prevalence and circulating strains of rotavirus (RV) among Chinese children under 5 years of age after the implantation of the RV vaccine.Material and methodsStudies published between 2019 and 2023, focused on RV-based diarrhea among children less than 5 years were systematically reviewed using PubMed, Embase, Web of Science, CNKI, Wanfang and SinoMed Data. We synthesized their findings to examine prevalence and genetic diversity of RV after the RV vaccine implementation using a fixed-effects or random-effects model.ResultsSeventeen studies met the inclusion criteria for this meta-analysis. The overall prevalence of RV was found to be 19.00%. The highest infection rate was noted in children aged 12-23months (25.79%), followed by those aged 24-35 months (23.91%), and 6-11 months (22.08%). The serotype G9 emerged as the most predominant RV genotype, accounting for 85.48% of infections, followed by G2 (7.70%), G8 (5.74%), G1 (4.86%), and G3 (3.21%). The most common P type was P[8], representing 64.02% of RV cases. Among G-P combinations, G9P[8] was the most frequent, responsible for 78.46% of RV infections, succeeded by G8P[8] (31.22%) and G3P[8] (8.11%).ConclusionDespite the variation of serotypes observed in China, the G1, G2, G3, G8 and G9 serotypes accounted for most RV strains. The genetic diversity analysis highlights the dynamic nature of RV genotypes, necessitating ongoing surveillance to monitor changes in strain distribution and inform future vaccine strategies. |
| first_indexed | 2024-04-24T08:58:43Z |
| format | Article |
| id | doaj.art-873cd364e78c49b38dbf1781cf3ff51b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T08:58:43Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-873cd364e78c49b38dbf1781cf3ff51b2024-04-16T05:00:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13644291364429Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysisYue Li0Sijie Wang1Sijie Wang2Fan Liang3Sashuang Teng4Fei Wang5Department of Immunization Program, Hongkou District Center for Disease Control and Prevention, Shanghai, ChinaShanghai Institute of Major Infectious Disease and Biosafety, and Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaKey Laboratory of Medical Molecular Virology of MoE&MoH, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Immunization Program, Hongkou District Center for Disease Control and Prevention, Shanghai, ChinaDepartment of Immunization Program, Hongkou District Center for Disease Control and Prevention, Shanghai, ChinaCentral Administrative Office, Hongkou District Center for Disease Control and Prevention, Shanghai, ChinaBackgroundThis meta-analysis was performed to assess the prevalence and circulating strains of rotavirus (RV) among Chinese children under 5 years of age after the implantation of the RV vaccine.Material and methodsStudies published between 2019 and 2023, focused on RV-based diarrhea among children less than 5 years were systematically reviewed using PubMed, Embase, Web of Science, CNKI, Wanfang and SinoMed Data. We synthesized their findings to examine prevalence and genetic diversity of RV after the RV vaccine implementation using a fixed-effects or random-effects model.ResultsSeventeen studies met the inclusion criteria for this meta-analysis. The overall prevalence of RV was found to be 19.00%. The highest infection rate was noted in children aged 12-23months (25.79%), followed by those aged 24-35 months (23.91%), and 6-11 months (22.08%). The serotype G9 emerged as the most predominant RV genotype, accounting for 85.48% of infections, followed by G2 (7.70%), G8 (5.74%), G1 (4.86%), and G3 (3.21%). The most common P type was P[8], representing 64.02% of RV cases. Among G-P combinations, G9P[8] was the most frequent, responsible for 78.46% of RV infections, succeeded by G8P[8] (31.22%) and G3P[8] (8.11%).ConclusionDespite the variation of serotypes observed in China, the G1, G2, G3, G8 and G9 serotypes accounted for most RV strains. The genetic diversity analysis highlights the dynamic nature of RV genotypes, necessitating ongoing surveillance to monitor changes in strain distribution and inform future vaccine strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364429/fullpentavalent rotavirus vaccinerotavirus genotypemeta-analysischildrenChina |
| spellingShingle | Yue Li Sijie Wang Sijie Wang Fan Liang Sashuang Teng Fei Wang Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis Frontiers in Immunology pentavalent rotavirus vaccine rotavirus genotype meta-analysis children China |
| title | Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis |
| title_full | Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis |
| title_fullStr | Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis |
| title_full_unstemmed | Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis |
| title_short | Prevalence and genetic diversity of rotavirus among children under 5 years of age in China: a meta-analysis |
| title_sort | prevalence and genetic diversity of rotavirus among children under 5 years of age in china a meta analysis |
| topic | pentavalent rotavirus vaccine rotavirus genotype meta-analysis children China |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364429/full |
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