1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide
Thepakorn Sathitkarnmanee, Sirirat Tribuddharat, Duangthida Nonlhaopol, Maneerat Thananun, Wilawan Somdee Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Background: We reported a 1-1-12 wash-in scheme for desflurane-nitrous oxide (N2O) low flow anesthe...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-02-01
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| Series: | Drug Design, Development and Therapy |
| Online Access: | http://www.dovepress.com/1-1-12-one-step-wash-in-scheme-for-desflurane-low-flow-anesthesia-perf-peer-reviewed-article-DDDT |
| _version_ | 1818063446385623040 |
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| author | Sathitkarnmanee T Tribuddharat S Nonlhaopol D Thananun M Somdee W |
| author_facet | Sathitkarnmanee T Tribuddharat S Nonlhaopol D Thananun M Somdee W |
| author_sort | Sathitkarnmanee T |
| collection | DOAJ |
| description | Thepakorn Sathitkarnmanee, Sirirat Tribuddharat, Duangthida Nonlhaopol, Maneerat Thananun, Wilawan Somdee Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Background: We reported a 1-1-12 wash-in scheme for desflurane-nitrous oxide (N2O) low flow anesthesia that is simple, rapid, and predictable. There remain some situations where N2O should be avoided, which limits the generalizability of this wash-in scheme. The objective of our study was to determine the performance of this scheme in contexts where N2O is not used.Methods: We recruited 106 patients scheduled for elective surgery under general anesthesia. After induction and intubation, wash-in was started with a fresh gas flow of air:O2 1:1 L/min and a vaporizer concentration of desflurane of 12%. Controlled ventilation was then adjusted to maintain PACO2 at 30–35 mmHg.Results: The alveolar concentration of desflurane (FAD) rose rapidly from 0% to 6% in 4 minutes in the same pattern as observed in our previous study in which N2O was used. An FAD of 7% was achieved in 6 minutes. An FAD of 1% to 7% occurred at 0.6, 1, 1.5, 2, 3, 4, and 6 minutes. The rise in heart rate during wash-in was statistically significant, although not clinically so. There was a slight but statistically significant decrease in blood pressure, but this had no clinical significance.Conclusion: Performance of the 1-1-12 wash-in scheme is independent of the use of N2O. Respective FADs of 1%, 2%, 3%, 4%, 5%, 6%, and 7% can be expected at 0.6, 1, 1.5, 2, 3, 4, and 6 minutes. Keywords: low flow anesthesia, wash-in, desflurane, air |
| first_indexed | 2024-12-10T14:20:14Z |
| format | Article |
| id | doaj.art-873df93688084dec8e8cfe9a314914ad |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-10T14:20:14Z |
| publishDate | 2015-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-873df93688084dec8e8cfe9a314914ad2022-12-22T01:45:12ZengDove Medical PressDrug Design, Development and Therapy1177-88812015-02-012015default977981205021-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxideSathitkarnmanee TTribuddharat SNonlhaopol DThananun MSomdee WThepakorn Sathitkarnmanee, Sirirat Tribuddharat, Duangthida Nonlhaopol, Maneerat Thananun, Wilawan Somdee Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand Background: We reported a 1-1-12 wash-in scheme for desflurane-nitrous oxide (N2O) low flow anesthesia that is simple, rapid, and predictable. There remain some situations where N2O should be avoided, which limits the generalizability of this wash-in scheme. The objective of our study was to determine the performance of this scheme in contexts where N2O is not used.Methods: We recruited 106 patients scheduled for elective surgery under general anesthesia. After induction and intubation, wash-in was started with a fresh gas flow of air:O2 1:1 L/min and a vaporizer concentration of desflurane of 12%. Controlled ventilation was then adjusted to maintain PACO2 at 30–35 mmHg.Results: The alveolar concentration of desflurane (FAD) rose rapidly from 0% to 6% in 4 minutes in the same pattern as observed in our previous study in which N2O was used. An FAD of 7% was achieved in 6 minutes. An FAD of 1% to 7% occurred at 0.6, 1, 1.5, 2, 3, 4, and 6 minutes. The rise in heart rate during wash-in was statistically significant, although not clinically so. There was a slight but statistically significant decrease in blood pressure, but this had no clinical significance.Conclusion: Performance of the 1-1-12 wash-in scheme is independent of the use of N2O. Respective FADs of 1%, 2%, 3%, 4%, 5%, 6%, and 7% can be expected at 0.6, 1, 1.5, 2, 3, 4, and 6 minutes. Keywords: low flow anesthesia, wash-in, desflurane, airhttp://www.dovepress.com/1-1-12-one-step-wash-in-scheme-for-desflurane-low-flow-anesthesia-perf-peer-reviewed-article-DDDT |
| spellingShingle | Sathitkarnmanee T Tribuddharat S Nonlhaopol D Thananun M Somdee W 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide Drug Design, Development and Therapy |
| title | 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide |
| title_full | 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide |
| title_fullStr | 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide |
| title_full_unstemmed | 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide |
| title_short | 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide |
| title_sort | 1 1 12 one step wash in scheme for desflurane low flow anesthesia performance without nitrous nbsp oxide |
| url | http://www.dovepress.com/1-1-12-one-step-wash-in-scheme-for-desflurane-low-flow-anesthesia-perf-peer-reviewed-article-DDDT |
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