The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status
Background: The evaluation of surgical margins in resected perihilar cholangiocarcinoma (PHCC) remains a challenging issue. Both ductal (DM) and radial margin (RM) should be considered to define true radical resections (R0). Although DM status is routinely described in pathological reports, RM statu...
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/24/6126 |
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| author | Mario De Bellis Maria Gaia Mastrosimini Simone Conci Sara Pecori Tommaso Campagnaro Claudia Castelli Paola Capelli Aldo Scarpa Alfredo Guglielmi Andrea Ruzzenente |
| author_facet | Mario De Bellis Maria Gaia Mastrosimini Simone Conci Sara Pecori Tommaso Campagnaro Claudia Castelli Paola Capelli Aldo Scarpa Alfredo Guglielmi Andrea Ruzzenente |
| author_sort | Mario De Bellis |
| collection | DOAJ |
| description | Background: The evaluation of surgical margins in resected perihilar cholangiocarcinoma (PHCC) remains a challenging issue. Both ductal (DM) and radial margin (RM) should be considered to define true radical resections (R0). Although DM status is routinely described in pathological reports, RM status is often overlooked. Therefore, the frequency of true R0 and its impact on survival might be biased. Objective: To improve the evaluation of RM status and investigate the impact of true R0 on survival. Methods: From 2014 to 2020, 90 patients underwent curative surgery for PHCC at Verona University Hospital, Verona, Italy. Both DM (proximal and distal biliary margin) and RM (hepatic, periductal, and vascular margin) status were evaluated by expert hepatobiliary pathologists. Patients with lymph-node metastases or positive surgical margins (R1) were candidates for adjuvant treatment. Clinicopathological and survival data were retrieved from an institutional database. Results: True R0 were 46% (41) and overall R1 were 54% (49). RM positivity resulted in being higher than DM positivity (48% versus 27%). Overall survival was better in patients with true R0 than in patients with R1 (median survival time: 53 vs. 28 months; <i>p</i> = 0.016). Likewise, the best recurrence-free survival was observed in R0 compared with R1 (median survival time: 32 vs. 15 months; <i>p</i> = 0.006). Multivariable analysis identified residual disease status as an independent prognostic factor of both OS (<i>p</i> = 0.009, HR = 2.68, 95% CI = 1.27–5.63) and RFS (<i>p</i> = 0.009, HR = 2.14, 95% CI = 1.20–3.83). Conclusion: Excellent survival was observed in true R0 patients. The improved evaluation of RM status is mandatory to properly stratify prognosis and select patients for adjuvant treatment. |
| first_indexed | 2024-03-09T17:14:27Z |
| format | Article |
| id | doaj.art-873e0c02d9444604a94bdcadd9b699a5 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:14:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-873e0c02d9444604a94bdcadd9b699a52023-11-24T13:46:35ZengMDPI AGCancers2072-66942022-12-011424612610.3390/cancers14246126The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin StatusMario De Bellis0Maria Gaia Mastrosimini1Simone Conci2Sara Pecori3Tommaso Campagnaro4Claudia Castelli5Paola Capelli6Aldo Scarpa7Alfredo Guglielmi8Andrea Ruzzenente9Department of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyDepartment of Surgery, Dentistry, Gynecology and Pediatrics, Division of General and Hepatobiliary Surgery, University of Verona, G.B. Rossi University Hospital, P. le L.A. Scuro 10, 37134 Verona, ItalyBackground: The evaluation of surgical margins in resected perihilar cholangiocarcinoma (PHCC) remains a challenging issue. Both ductal (DM) and radial margin (RM) should be considered to define true radical resections (R0). Although DM status is routinely described in pathological reports, RM status is often overlooked. Therefore, the frequency of true R0 and its impact on survival might be biased. Objective: To improve the evaluation of RM status and investigate the impact of true R0 on survival. Methods: From 2014 to 2020, 90 patients underwent curative surgery for PHCC at Verona University Hospital, Verona, Italy. Both DM (proximal and distal biliary margin) and RM (hepatic, periductal, and vascular margin) status were evaluated by expert hepatobiliary pathologists. Patients with lymph-node metastases or positive surgical margins (R1) were candidates for adjuvant treatment. Clinicopathological and survival data were retrieved from an institutional database. Results: True R0 were 46% (41) and overall R1 were 54% (49). RM positivity resulted in being higher than DM positivity (48% versus 27%). Overall survival was better in patients with true R0 than in patients with R1 (median survival time: 53 vs. 28 months; <i>p</i> = 0.016). Likewise, the best recurrence-free survival was observed in R0 compared with R1 (median survival time: 32 vs. 15 months; <i>p</i> = 0.006). Multivariable analysis identified residual disease status as an independent prognostic factor of both OS (<i>p</i> = 0.009, HR = 2.68, 95% CI = 1.27–5.63) and RFS (<i>p</i> = 0.009, HR = 2.14, 95% CI = 1.20–3.83). Conclusion: Excellent survival was observed in true R0 patients. The improved evaluation of RM status is mandatory to properly stratify prognosis and select patients for adjuvant treatment.https://www.mdpi.com/2072-6694/14/24/6126surgical marginradial marginperiductal marginresidual diseasehilar cholangiocarcinoma |
| spellingShingle | Mario De Bellis Maria Gaia Mastrosimini Simone Conci Sara Pecori Tommaso Campagnaro Claudia Castelli Paola Capelli Aldo Scarpa Alfredo Guglielmi Andrea Ruzzenente The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status Cancers surgical margin radial margin periductal margin residual disease hilar cholangiocarcinoma |
| title | The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status |
| title_full | The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status |
| title_fullStr | The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status |
| title_full_unstemmed | The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status |
| title_short | The Prognostic Role of True Radical Resection in Perihilar Cholangiocarcinoma after Improved Evaluation of Radial Margin Status |
| title_sort | prognostic role of true radical resection in perihilar cholangiocarcinoma after improved evaluation of radial margin status |
| topic | surgical margin radial margin periductal margin residual disease hilar cholangiocarcinoma |
| url | https://www.mdpi.com/2072-6694/14/24/6126 |
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