Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial

Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial

Objective: Major depressive disorder (MDD) is related to glutamatergic dysfunction. Antagonists of glutamatergic N-methyl-D-aspartate receptor (NMDAR), such as ketamine, have antidepressant properties. Nitrous oxide (N2O) is also a NMDAR antagonist. Thus, this study aimed to evaluate the effects of...

Full description

Bibliographic Details
Main Authors: Mara C. Guimarães, Tiago M. Guimarães, Jaime E. Hallak, João Abrão, João P. Machado-de-Sousa
Format: Article
Language:English
Published: Associação Brasileira de Psiquiatria (ABP) 2021-02-01
Series:Brazilian Journal of Psychiatry
Subjects:
nitrous oxide
major depressive disorder
glutamatergic system
NMDA receptor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462021000500484&tlng=en

Similar Items

Similar Items