Aflatoxin B1 induces infertility, fetal deformities, and potential therapies
Aflatoxin B1 (AFB1) is a subsidiary poisonous metabolite, archetypally spawned by Aspergillus flavus and A. parasiticus, which are often isolated in warm or tropical countries across the world. AFB1 is capable of disrupting the functioning of several reproductive endocrine glands by interrupting the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-01-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2024-0907 |
| _version_ | 1827370194348015616 |
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| author | Francis Sullibie Kortei Nii Korley Sackey Marian Richard Seidu A. |
| author_facet | Francis Sullibie Kortei Nii Korley Sackey Marian Richard Seidu A. |
| author_sort | Francis Sullibie |
| collection | DOAJ |
| description | Aflatoxin B1 (AFB1) is a subsidiary poisonous metabolite, archetypally spawned by Aspergillus flavus and A. parasiticus, which are often isolated in warm or tropical countries across the world. AFB1 is capable of disrupting the functioning of several reproductive endocrine glands by interrupting the enzymes and their substrates that are liable for the synthesis of various hormones in both males and females. In men, AFB1 is capable of hindering testicular development, testicular degeneration, and reduces reproductive capabilities. In women, a direct antagonistic interaction of AFB1 with steroid hormone receptors influencing gonadal hormone production of estrogen and progesterone was responsible for AFB1-associated infertility. AFB1 is potentially teratogenic and is responsible for the development of malformation in humans and animals. Soft-tissue anomalies such as internal hydrocephalus, microphthalmia, cardiac defects, augmented liver lobes, reproductive changes, immune modifications, behavioral changes and predisposition of animals and humans to neoplasm development are AFB1-associated anomalies. Substances such as esculin, selenium, gynandra extract, vitamins C and E, oltipraz, and CDDO-Im are potential therapies for AFB1. Thus, this review elucidates the pivotal pathogenic roles of AFB1 in infertility, fetal deformities, and potential therapies because AFB1 toxicity is a key problem globally. |
| first_indexed | 2024-03-08T10:10:55Z |
| format | Article |
| id | doaj.art-87403c4bc4c04f1785236a2948234014 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-03-08T10:10:55Z |
| publishDate | 2024-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-87403c4bc4c04f1785236a29482340142024-01-29T08:48:31ZengDe GruyterOpen Medicine2391-54632024-01-01191637010.1515/med-2024-0907Aflatoxin B1 induces infertility, fetal deformities, and potential therapiesFrancis Sullibie0Kortei Nii Korley1Sackey Marian2Richard Seidu A.3Department of Obstetrics and Gynecology, Ho Teaching Hospital, P.O. Box MA-374, Ho, GhanaDepartment of Nutrition and Dietetics, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, GhanaDepartment of Pharmacy, Ho Teaching Hospital, P.O. Box MA-374, Ho, GhanaDepartment of Medicine, Princefield University, P. O. Box MA128, Ho, GhanaAflatoxin B1 (AFB1) is a subsidiary poisonous metabolite, archetypally spawned by Aspergillus flavus and A. parasiticus, which are often isolated in warm or tropical countries across the world. AFB1 is capable of disrupting the functioning of several reproductive endocrine glands by interrupting the enzymes and their substrates that are liable for the synthesis of various hormones in both males and females. In men, AFB1 is capable of hindering testicular development, testicular degeneration, and reduces reproductive capabilities. In women, a direct antagonistic interaction of AFB1 with steroid hormone receptors influencing gonadal hormone production of estrogen and progesterone was responsible for AFB1-associated infertility. AFB1 is potentially teratogenic and is responsible for the development of malformation in humans and animals. Soft-tissue anomalies such as internal hydrocephalus, microphthalmia, cardiac defects, augmented liver lobes, reproductive changes, immune modifications, behavioral changes and predisposition of animals and humans to neoplasm development are AFB1-associated anomalies. Substances such as esculin, selenium, gynandra extract, vitamins C and E, oltipraz, and CDDO-Im are potential therapies for AFB1. Thus, this review elucidates the pivotal pathogenic roles of AFB1 in infertility, fetal deformities, and potential therapies because AFB1 toxicity is a key problem globally.https://doi.org/10.1515/med-2024-0907afb1 infertilitytestisovarymalformationsmarkers |
| spellingShingle | Francis Sullibie Kortei Nii Korley Sackey Marian Richard Seidu A. Aflatoxin B1 induces infertility, fetal deformities, and potential therapies Open Medicine afb1 infertility testis ovary malformations markers |
| title | Aflatoxin B1 induces infertility, fetal deformities, and potential therapies |
| title_full | Aflatoxin B1 induces infertility, fetal deformities, and potential therapies |
| title_fullStr | Aflatoxin B1 induces infertility, fetal deformities, and potential therapies |
| title_full_unstemmed | Aflatoxin B1 induces infertility, fetal deformities, and potential therapies |
| title_short | Aflatoxin B1 induces infertility, fetal deformities, and potential therapies |
| title_sort | aflatoxin b1 induces infertility fetal deformities and potential therapies |
| topic | afb1 infertility testis ovary malformations markers |
| url | https://doi.org/10.1515/med-2024-0907 |
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