Molecular evolution of the transmembrane domains of G protein-coupled receptors.

Molecular evolution of the transmembrane domains of G protein-coupled receptors.

G protein-coupled receptors (GPCRs) are a superfamily of integral membrane proteins vital for signaling and are important targets for pharmaceutical intervention in humans. Previously, we identified a group of ten amino acid positions (called key positions), within the seven transmembrane domain (7T...

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Bibliographic Details
Main Authors: Sarosh N Fatakia, Stefano Costanzi, Carson C Chow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3221663?pdf=render

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