Tracking the phage trends: A comprehensive review of applications in therapy and food production
In the present scenario, the challenge of emerging antimicrobial resistance is affecting human health globally. The increasing incidences of multidrug-resistant infections have become harder to treat, causing high morbidity, and mortality, and are posing extensive financial loss. Limited discovery o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.993990/full |
| _version_ | 1811304682117660672 |
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| author | Anu Bala Jaglan Taruna Anand Ravikant Verma Medhavi Vashisth Nitin Virmani B. C. Bera R. K. Vaid B. N. Tripathi |
| author_facet | Anu Bala Jaglan Taruna Anand Ravikant Verma Medhavi Vashisth Nitin Virmani B. C. Bera R. K. Vaid B. N. Tripathi |
| author_sort | Anu Bala Jaglan |
| collection | DOAJ |
| description | In the present scenario, the challenge of emerging antimicrobial resistance is affecting human health globally. The increasing incidences of multidrug-resistant infections have become harder to treat, causing high morbidity, and mortality, and are posing extensive financial loss. Limited discovery of new antibiotic molecules has further complicated the situation and has forced researchers to think and explore alternatives to antibiotics. This has led to the resurgence of the bacteriophages as an effective alternative as they have a proven history in the Eastern world where lytic bacteriophages have been used since their first implementation over a century ago. To help researchers and clinicians towards strengthening bacteriophages as a more effective, safe, and economical therapeutic alternative, the present review provides an elaborate narrative about the important aspects of bacteriophages. It abridges the prerequisite essential requirements of phage therapy, the role of phage biobank, and the details of immune responses reported while using bacteriophages in the clinical trials/compassionate grounds by examining the up-to-date case reports and their effects on the human gut microbiome. This review also discusses the potential of bacteriophages as a biocontrol agent against food-borne diseases in the food industry and aquaculture, in addition to clinical therapy. It finishes with a discussion of the major challenges, as well as phage therapy and phage-mediated biocontrols future prospects. |
| first_indexed | 2024-04-13T08:11:39Z |
| format | Article |
| id | doaj.art-874342a9bdf74b14b0dffae8dc2c9ead |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T08:11:39Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-874342a9bdf74b14b0dffae8dc2c9ead2022-12-22T02:54:57ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-11-011310.3389/fmicb.2022.993990993990Tracking the phage trends: A comprehensive review of applications in therapy and food productionAnu Bala Jaglan0Taruna Anand1Ravikant Verma2Medhavi Vashisth3Nitin Virmani4B. C. Bera5R. K. Vaid6B. N. Tripathi7Department of Zoology and Aquaculture, Chaudhary Charan Singh Haryana Agricultural University, Hisar, IndiaICAR – National Research Centre on Equines, Hisar, IndiaDepartment of Zoology and Aquaculture, Chaudhary Charan Singh Haryana Agricultural University, Hisar, IndiaDepartment of Molecular Biology, Biotechnology, and Bioinformatics, Chaudhary Charan Singh Haryana Agricultural University, Hisar, IndiaICAR – National Research Centre on Equines, Hisar, IndiaICAR – National Research Centre on Equines, Hisar, IndiaICAR – National Research Centre on Equines, Hisar, IndiaAnimal Science Division, Indian Council of Agricultural Research, Krishi Bhawan, New Delhi, IndiaIn the present scenario, the challenge of emerging antimicrobial resistance is affecting human health globally. The increasing incidences of multidrug-resistant infections have become harder to treat, causing high morbidity, and mortality, and are posing extensive financial loss. Limited discovery of new antibiotic molecules has further complicated the situation and has forced researchers to think and explore alternatives to antibiotics. This has led to the resurgence of the bacteriophages as an effective alternative as they have a proven history in the Eastern world where lytic bacteriophages have been used since their first implementation over a century ago. To help researchers and clinicians towards strengthening bacteriophages as a more effective, safe, and economical therapeutic alternative, the present review provides an elaborate narrative about the important aspects of bacteriophages. It abridges the prerequisite essential requirements of phage therapy, the role of phage biobank, and the details of immune responses reported while using bacteriophages in the clinical trials/compassionate grounds by examining the up-to-date case reports and their effects on the human gut microbiome. This review also discusses the potential of bacteriophages as a biocontrol agent against food-borne diseases in the food industry and aquaculture, in addition to clinical therapy. It finishes with a discussion of the major challenges, as well as phage therapy and phage-mediated biocontrols future prospects.https://www.frontiersin.org/articles/10.3389/fmicb.2022.993990/fullantibiotic resistancebacteriophagecompassionate phage therapybiocontrolaquaculture |
| spellingShingle | Anu Bala Jaglan Taruna Anand Ravikant Verma Medhavi Vashisth Nitin Virmani B. C. Bera R. K. Vaid B. N. Tripathi Tracking the phage trends: A comprehensive review of applications in therapy and food production Frontiers in Microbiology antibiotic resistance bacteriophage compassionate phage therapy biocontrol aquaculture |
| title | Tracking the phage trends: A comprehensive review of applications in therapy and food production |
| title_full | Tracking the phage trends: A comprehensive review of applications in therapy and food production |
| title_fullStr | Tracking the phage trends: A comprehensive review of applications in therapy and food production |
| title_full_unstemmed | Tracking the phage trends: A comprehensive review of applications in therapy and food production |
| title_short | Tracking the phage trends: A comprehensive review of applications in therapy and food production |
| title_sort | tracking the phage trends a comprehensive review of applications in therapy and food production |
| topic | antibiotic resistance bacteriophage compassionate phage therapy biocontrol aquaculture |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.993990/full |
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