Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy
Objective: To assess the effectiveness of intravenous (iv) paracetamol (PCM) infusion in prolonging the duration of analgesia following spinal anesthesia and to determine patients’ satisfaction with pain relief. Materials and Methods: This was a double-blind, randomized, controlled study. A total of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | International Journal of Medicine and Health Development |
| Subjects: | |
| Online Access: | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2021;volume=26;issue=1;spage=37;epage=43;aulast=Eya |
| _version_ | 1798018671291924480 |
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| author | Jonathan C Eya Fidelis A Onyekwulu Adaobi O Amucheazi Obinna V Ajuzieogu |
| author_facet | Jonathan C Eya Fidelis A Onyekwulu Adaobi O Amucheazi Obinna V Ajuzieogu |
| author_sort | Jonathan C Eya |
| collection | DOAJ |
| description | Objective: To assess the effectiveness of intravenous (iv) paracetamol (PCM) infusion in prolonging the duration of analgesia following spinal anesthesia and to determine patients’ satisfaction with pain relief. Materials and Methods: This was a double-blind, randomized, controlled study. A total of 126 adult American Society of Anesthesiologists physical status I or II women scheduled for elective myomectomy under spinal anesthesia were enrolled in the study. Patients were randomly allocated into two groups. PCM group (group A) [n = 63] received 100mL of 1g PCM and Normal saline group (group B) [n = 63] received 100mL of normal saline after spinal anesthesia was established. Statistical analysis was done using Statistical Package for Social Sciences, version 17. Results: There was no statistical difference between the groups in terms of age, weight, and body mass index. The mean time to first analgesic demand was 4.75 ± 1.59 h in group A and 2.23 ± 0.15 h in group B (P < 0.001), while the mean dose of additional analgesic was significantly lower in group A (11.81 ± 2.50 µg) when compared to group B (255.49 ± 140.80 µg), P < 0.001. In group A, 75.8% expressed excellent satisfaction with pain relief while 62.9% of patient in group B reported poor satisfaction with pain relief (χ2 = 87.600, P < 0.001). Conclusion: Intravenous infusion of 1g PCM is effective in prolonging the duration of analgesia following spinal anesthesia for myomectomy. |
| first_indexed | 2024-04-11T16:28:14Z |
| format | Article |
| id | doaj.art-87434b4b6ae84252b13d1259ad95e76d |
| institution | Directory Open Access Journal |
| issn | 2635-3695 |
| language | English |
| last_indexed | 2024-04-11T16:28:14Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Medicine and Health Development |
| spelling | doaj.art-87434b4b6ae84252b13d1259ad95e76d2022-12-22T04:14:07ZengWolters Kluwer Medknow PublicationsInternational Journal of Medicine and Health Development2635-36952021-01-01261374310.4103/ijmh.IJMH_25_20Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomyJonathan C EyaFidelis A OnyekwuluAdaobi O AmucheaziObinna V AjuzieoguObjective: To assess the effectiveness of intravenous (iv) paracetamol (PCM) infusion in prolonging the duration of analgesia following spinal anesthesia and to determine patients’ satisfaction with pain relief. Materials and Methods: This was a double-blind, randomized, controlled study. A total of 126 adult American Society of Anesthesiologists physical status I or II women scheduled for elective myomectomy under spinal anesthesia were enrolled in the study. Patients were randomly allocated into two groups. PCM group (group A) [n = 63] received 100mL of 1g PCM and Normal saline group (group B) [n = 63] received 100mL of normal saline after spinal anesthesia was established. Statistical analysis was done using Statistical Package for Social Sciences, version 17. Results: There was no statistical difference between the groups in terms of age, weight, and body mass index. The mean time to first analgesic demand was 4.75 ± 1.59 h in group A and 2.23 ± 0.15 h in group B (P < 0.001), while the mean dose of additional analgesic was significantly lower in group A (11.81 ± 2.50 µg) when compared to group B (255.49 ± 140.80 µg), P < 0.001. In group A, 75.8% expressed excellent satisfaction with pain relief while 62.9% of patient in group B reported poor satisfaction with pain relief (χ2 = 87.600, P < 0.001). Conclusion: Intravenous infusion of 1g PCM is effective in prolonging the duration of analgesia following spinal anesthesia for myomectomy.http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2021;volume=26;issue=1;spage=37;epage=43;aulast=Eyaintravenous paracetamol infusionmyomectomyspinal anesthesia |
| spellingShingle | Jonathan C Eya Fidelis A Onyekwulu Adaobi O Amucheazi Obinna V Ajuzieogu Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy International Journal of Medicine and Health Development intravenous paracetamol infusion myomectomy spinal anesthesia |
| title | Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy |
| title_full | Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy |
| title_fullStr | Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy |
| title_full_unstemmed | Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy |
| title_short | Efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy |
| title_sort | efficacy of intravenous paracetamol infusion for prolongation of analgesia under spinal anesthesia for myomectomy |
| topic | intravenous paracetamol infusion myomectomy spinal anesthesia |
| url | http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2021;volume=26;issue=1;spage=37;epage=43;aulast=Eya |
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