Genetic influences on the development of fibrosis in Crohn’s Disease
Fibrostenotic strictures are an important complication in patients with Crohn’s Disease, very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual, and is influenced by an interplay with environmental, immunological and disease-related factors. A deeper...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmed.2016.00024/full |
| _version_ | 1819211078972735488 |
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| author | Bram eVerstockt Bram eVerstockt Isabelle eCleynen |
| author_facet | Bram eVerstockt Bram eVerstockt Isabelle eCleynen |
| author_sort | Bram eVerstockt |
| collection | DOAJ |
| description | Fibrostenotic strictures are an important complication in patients with Crohn’s Disease, very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual, and is influenced by an interplay with environmental, immunological and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here we review the genetic factors that have been associated with the development of fibrosis in patients with Crohn’s disease, as well as their potential pathophysiological mechanism(s). We also hypothesize on clinical implications if any, and future research directions. |
| first_indexed | 2024-12-23T06:21:22Z |
| format | Article |
| id | doaj.art-87438035faf8492592b8a41fec2c3558 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-23T06:21:22Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-87438035faf8492592b8a41fec2c35582022-12-21T17:57:11ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2016-05-01310.3389/fmed.2016.00024203740Genetic influences on the development of fibrosis in Crohn’s DiseaseBram eVerstockt0Bram eVerstockt1Isabelle eCleynen2University of Cambridge School of Clinical MedicineKU LeuvenKU LeuvenFibrostenotic strictures are an important complication in patients with Crohn’s Disease, very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual, and is influenced by an interplay with environmental, immunological and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here we review the genetic factors that have been associated with the development of fibrosis in patients with Crohn’s disease, as well as their potential pathophysiological mechanism(s). We also hypothesize on clinical implications if any, and future research directions.http://journal.frontiersin.org/Journal/10.3389/fmed.2016.00024/fullAutophagyFibrosisGeneticsCrohn’s DiseaseNod2stricturing disease |
| spellingShingle | Bram eVerstockt Bram eVerstockt Isabelle eCleynen Genetic influences on the development of fibrosis in Crohn’s Disease Frontiers in Medicine Autophagy Fibrosis Genetics Crohn’s Disease Nod2 stricturing disease |
| title | Genetic influences on the development of fibrosis in Crohn’s Disease |
| title_full | Genetic influences on the development of fibrosis in Crohn’s Disease |
| title_fullStr | Genetic influences on the development of fibrosis in Crohn’s Disease |
| title_full_unstemmed | Genetic influences on the development of fibrosis in Crohn’s Disease |
| title_short | Genetic influences on the development of fibrosis in Crohn’s Disease |
| title_sort | genetic influences on the development of fibrosis in crohn s disease |
| topic | Autophagy Fibrosis Genetics Crohn’s Disease Nod2 stricturing disease |
| url | http://journal.frontiersin.org/Journal/10.3389/fmed.2016.00024/full |
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